Release of cationic drugs from loaded clay minerals

被引：52

作者：

Fejér, I

Kata, M

Erös, I

Berkesi, O

Dékány, I

机构：

[1] Univ Szeged, Dept Pharmaceut Technol, H-6720 Szeged, Hungary

[2] Univ Szeged, Dept Phys Chem, H-6720 Szeged, Hungary

[3] Univ Szeged, Dept Colloid Chem, H-6720 Szeged, Hungary

[4] Hungarian Acad Sci, Nanostructured Mat Res Grp, H-6720 Szeged, Hungary

来源：

COLLOID AND POLYMER SCIENCE | 2001年 / 279卷 / 12期

关键词：

montmorillonite; promethazine chloride; X-ray diffraction measurements; desorption; drug intercalation;

D O I：

10.1007/s003960100527

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The adsorption of promethazine chloride [10-(2-dimethylammonium propyl) fenothiazine chloride] and buformin hydrochloride (1-butylbiguanidine chloride) on montmorillonite was studied in previous work. The present article focuses on the desorption of these molecules from their organocomplexes in a medium of artificial intestinal juice (pH 7.0+/-0.1) at the temperature of the human body (37+/-0.5 degreesC). The desorption was investigated by kinetic studies, basal spacing measurements and Fourier transform IR studies. Important quantitative differences were observed: buformin, which adsorbed in a monolayer coverage, exhibited a very high desorption rate, whereas promethazine formed a pseudotrilayer arrangement and showed a lower dissolution rate.

引用

页码：1177 / 1182

页数：6

共 5 条

[1] Adsorption-desorption behavior of acrylic-maleic acid copolymer at clay minerals [J].