The burning question: Why is smoking a risk factor for pancreatic cancer?

被引：42
作者：
Pandol, Stephen J. [1 ]
Apte, Minoti V. [2 ]
Wilson, Jeremy S. [2 ]
Gukovskaya, Anna S. [1 ]
Edderkaoui, Mouad [1 ]
机构：
[1] Univ Calif Los Angeles, Vet Affairs Greater Angeles Healthcare Syst, Los Angeles, CA 90073 USA
[2] Univ New S Wales, S Western Sydney Clin Sch, Pancreat Res Grp, Sydney, NSW, Australia
来源：
PANCREATOLOGY | 2012年 / 12卷 / 04期
关键词：
Smoking; Pancreatic cancer; Fibrosis; Inflammation; TOBACCO-SPECIFIC CARCINOGEN; CIGARETTE-SMOKING; STELLATE CELLS; LUNG-CANCER; NICOTINE; MICROENVIRONMENT; ADENOCARCINOMA; CONTRIBUTE; RATS; 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE;
D O I：
10.1016/j.pan.2012.06.002
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease. The prognosis is poor; less than 5% of those diagnosed are still alive five years after diagnosis, and complete remission is still rare. Tobacco smoking is a major risk factor of pancreatic cancer. However, the mechanism(s) through which it causes the disease remains unknown. Accumulating evidence indicates that carcinogenic compounds in cigarette smoke stimulate pancreatic cancer progression through induction of inflammation and fibrosis which act in concert with genetic factors leading to the inhibition of cell death and stimulation of proliferation resulting in the promotion of the PDAC. Copyright (c) 2012, LAP and EPC. Published by Elsevier India, a division of Reed Elsevier India Pvt. Ltd. All rights reserved.
引用
收藏
页码：344 / 349
页数：6
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