The implications of the shared genetics of psychiatric disorders

被引：100
作者：
O'Donovan, Michael C. [1 ]
Owen, Michael J. [1 ]
机构：
[1] Cardiff Univ, Sch Med, Div Psychiat & Clin Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, S Glam, Wales
来源：
NATURE MEDICINE | 2016年 / 22卷 / 11期
基金：
英国医学研究理事会;
关键词：
COPY NUMBER VARIANTS; GLOBAL BURDEN; SCHIZOPHRENIA; DISEASE; RISK; LOCI; PSYCHOPATHOLOGY; CHALLENGES; PLEIOTROPY; MUTATIONS;
D O I：
10.1038/nm.4196
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent genomic studies have revealed the highly polygenic nature of psychiatric disorders, including schizophrenia, bipolar disorder and major depressive disorder. Many of the individual genetic associations are shared across multiple disorders in a way that points to extensive biological pleiotropy and further challenges the biological validity of existing diagnostic approaches. Here we argue that the existence of risk alleles specific to a single diagnostic category is unlikely. We also highlight some of the important clinical repercussions of pleiotropy.
引用
收藏
页码：1214 / 1219
页数：6
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