Palmitoylation and the trafficking of peripheral membrane proteins

被引:28
|
作者
Chamberlain, Luke H. [1 ]
Lemonidis, Kimon [1 ]
Sanchez-Perez, Maria [1 ]
Werno, Martin W. [1 ]
Gorleku, Oforiwa A. [1 ]
Greaves, Jennifer [1 ]
机构
[1] Univ Strathclyde, Strathdyde Inst Pharm & Biomed Sci, Glasgow G4 0RE, Lanark, Scotland
基金
英国惠康基金; 英国医学研究理事会;
关键词
cysteine-string protein; DHHC protein; palmitoylation; 25 kDa synaptosome-associated protein (SNAP25); CYSTEINE-STRING PROTEIN; PLASMA-MEMBRANE; SYNAPTOTAGMIN-I; RICH DOMAIN; PC12; CELLS; CAAX MOTIF; RAS; PATHWAY; SNAP-25; SNAP25;
D O I
10.1042/BST20120243
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Palmitoylation, the attachment of palmitate and other fatty acids on to cysteine residues, is a common post-translational modification of both integral and peripheral membrane proteins. Dynamic palmitoylation controls the intracellular distribution of peripheral membrane proteins by regulating membrane-cytosol exchange and/or by modifying the flux of the proteins through vesicular transport systems.
引用
收藏
页码:62 / 66
页数:5
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