Streptococcus pneumoniae: the evolution of antimicrobial resistance to beta-lactams, fluoroquinolones and macrolides

被引:72
作者
Cornick, J. E. [1 ,2 ]
Bentley, S. D. [3 ]
机构
[1] Malawi Liverpool Wellcome Clin Res Programme, Blantyre 3, Malawi
[2] Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 3BX, Merseyside, England
[3] Wellcome Trust Sanger Inst, Cambridge, England
关键词
Streptococcus pneumoniae; Evolution; Antimicrobial resistance; Beta-lactams; Fluoroquinolones; Macrolides; PNEUMOCOCCAL CONJUGATE VACCINE; PENICILLIN-BINDING PROTEINS; DNA TOPOISOMERASE-IV; UNITED-STATES; MOLECULAR CHARACTERIZATION; ERYTHROMYCIN RESISTANCE; REDUCED SUSCEPTIBILITY; GENETIC ELEMENTS; CLONAL COMPLEX; ADULT PATIENTS;
D O I
10.1016/j.micinf.2012.01.012
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Multi drug resistant Streptococcus pneumoniae constitute a major public health concern worldwide. In this review we discuss how the transformable nature of the pneumococcus, in parallel with antimicrobial induced stress, contributes to the evolution of antimicrobial resistance; and how the introduction of the pneumococcal conjugate vaccine has affected the situation. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:573 / 583
页数:11
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