Cardioprotective Role of Melatonin in Acute Myocardial Infarction

被引：63

作者：

Fu, Zhenhong ^{[1
]}

Jiao, Yang ^{[1
]}

Wang, Jihang ^{[1
]}

Zhang, Ying ^{[1
]}

Shen, Mingzhi ^{[1
]}

Reiter, Russel J. ^{[2
,3
]}

Xi, Qing ^{[4
]}

Chen, Yundai ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Cardiol, Beijing, Peoples R China

[2] UT Hlth San Antonio, Dept Cellular & Struct Biol, San Antonio, TX USA

[3] Univ Texas San Antonio, San Antonio Cellular Therapeut Inst, Dept Biol, Coll Sci, San Antonio, TX USA

[4] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Beijing, Peoples R China

来源：

FRONTIERS IN PHYSIOLOGY | 2020年 / 11卷

基金：

中国国家自然科学基金;

关键词：

melatonin; cardioprotective; cardiomyocyte; myocardial infarction; mitochondrion; ISCHEMIA-REPERFUSION INJURY; DOXORUBICIN-INDUCED CARDIOTOXICITY; OXIDATIVE STRESS; ISCHEMIA/REPERFUSION INJURY; MITOCHONDRIAL DYSFUNCTION; MOLECULAR-MECHANISMS; CELL-DEATH; ENDOTHELIAL-CELLS; HEART-FAILURE; PROTECTS;

D O I：

10.3389/fphys.2020.00366

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Melatonin is a pleiotropic, indole secreted, and synthesized by the human pineal gland. Melatonin has biological effects including anti-apoptosis, protecting mitochondria, anti-oxidation, anti-inflammation, and stimulating target cells to secrete cytokines. Its protective effect on cardiomyocytes in acute myocardial infarction (AMI) has caused widespread interest in the actions of this molecule. The effects of melatonin against oxidative stress, promoting autophagic repair of cells, regulating immune and inflammatory responses, enhancing mitochondrial function, and relieving endoplasmic reticulum stress, play crucial roles in protecting cardiomyocytes from infarction. Mitochondrial apoptosis and dysfunction are common occurrence in cardiomyocyte injury after myocardial infarction. This review focuses on the targets of melatonin in protecting cardiomyocytes in AMI, the main molecular signaling pathways that melatonin influences in its endogenous protective role in myocardial infarction, and the developmental prospect of melatonin in myocardial infarction treatment.

引用

页数：15

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