Nasopharyngeal Microbiota Profiling of SARS-CoV-2 Infected Patients

被引：84

作者：

De Maio, Flavio ^{[1
]}

Posteraro, Brunella ^{[2
]}

Ponziani, Francesca Romana ^{[2
]}

Cattani, Paola ^{[1
]}

Gasbarrini, Antonio ^{[2
]}

Sanguinetti, Maurizio ^{[1
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Lab & Infettivol, Largo A Gemelli 8, I-00168 Rome, Italy

[2] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Gastroenterol Endocrinometab & N, Rome, Italy

来源：

BIOLOGICAL PROCEDURES ONLINE | 2020年 / 22卷 / 01期

关键词：

Nasopharynx; Bacterial community; SARS-CoV-2; infection; 16S rRNA sequencing;

D O I：

10.1186/s12575-020-00131-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We analyzed the bacterial communities of the nasopharynx in 40 SARS-CoV-2 infected and uninfected patients. All infected patients had a mild COVID-19 disease. We did not find statistically significant differences in either bacterial richness and diversity or composition. These findings suggest a nasopharyngeal microbiota at least early resilient to SARS-CoV-2 infection.

引用

页数：4

共 23 条

[1]

[Anonymous], RADIOLOGY

[2]

[Anonymous], 2020, Interim Virtual Encounter Guidance During COVID-19 National Emergency

[3]

Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]

[4] A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster [J].

Chan, Jasper Fuk-Woo ;

Yuan, Shuofeng ;

Kok, Kin-Hang ;

To, Kelvin Kai-Wang ;

Chu, Hin ;

Yang, Jin ;

Xing, Fanfan ;

Liu, Jieling ;

Yip, Cyril Chik-Yan ;

Poon, Rosana Wing-Shan ;

Tsoi, Hoi-Wah ;

Lo, Simon Kam-Fai ;

Chan, Kwok-Hung ;

Poon, Vincent Kwok-Man ;

Chan, Wan-Mui ;

Ip, Jonathan Daniel ;

Cai, Jian-Piao ;

Cheng, Vincent Chi-Chung ;

Chen, Honglin ;

Hui, Christopher Kim-Ming ;

Yuen, Kwok-Yung .

LANCET, 2020, 395 (10223) :514-523

[5] Topographical Continuity of Bacterial Populations in the Healthy Human Respiratory Tract [J].

Charlson, Emily S. ;

Bittinger, Kyle ;

Haas, Andrew R. ;

Fitzgerald, Ayannah S. ;

Frank, Ian ;

Yadav, Anjana ;

Bushman, Frederic D. ;

Collman, Ronald G. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 184 (08) :957-963

[6]

Ding T, 2019, MBIO, V10, pe01296

[7] Review of chest CT manifestations of COVID-19 infection [J].

El Homsi, Maria ;

Chung, Michael ;

Bernheim, Adam ;

Jacobi, Adam ;

King, Michael J. ;

Lewis, Sara ;

Taouli, Bachir .

EUROPEAN JOURNAL OF RADIOLOGY OPEN, 2020, 7

[8] A Metagenomic Analysis of Pandemic Influenza A (2009 H1N1) Infection in Patients from North America [J].

Greninger, Alexander L. ;

Chen, Eunice C. ;

Sittler, Taylor ;

Scheinerman, Alex ;

Roubinian, Nareg ;

Yu, Guixia ;

Kim, Edward ;

Pillai, Dylan R. ;

Guyard, Cyril ;

Mazzulli, Tony ;

Isa, Pavel ;

Arias, Carlos F. ;

Hackett, John, Jr. ;

Schochetman, Gerald ;

Miller, Steve ;

Tang, Patrick ;

Chiu, Charles Y. .

PLOS ONE, 2010, 5 (10)

[9]

Hall M, 2018, METHODS MOL BIOL, V1849, P113, DOI 10.1007/978-1-4939-8728-3_8

[10] Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia [J].

Hanada, Shigeo ;

Pirzadeh, Mina ;

Carver, Kyle Y. ;

Deng, Jane C. .

FRONTIERS IN IMMUNOLOGY, 2018, 9

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