A case-control study of microRNA polymorphisms in gastric cancer screening by SNP chip combined with time of flight mass spectrometry

被引：8

作者：

Wu, Chuancheng ^{[1
,2
]}

Han, Renjie ^{[1
,2
,3
]}

Yang, Shuangfeng ^{[1
,2
]}

Jiang, Yu ^{[1
,2
]}

Shu, Zhixiong ^{[1
,2
]}

Liu, Jin ^{[1
]}

Ji, Shumi ^{[1
,2
]}

Yan, Wei ^{[4
]}

Liu, Baoying ^{[1
,2
]}

机构：

[1] Fujian Med Univ, Sch Publ Hlth, 1 Xueyuan Rd, Fuzhou 350122, Minhou, Peoples R China

[2] Fujian Prov Key Lab Environm Factors & Canc, 1 Xueyuan Rd, Fuzhou 350122, Minhou, Peoples R China

[3] Fuzhou Ctr Dis Control & Prevent, Dept Occupat Hlth, Fuzhou 350004, Fujian, Peoples R China

[4] Hosp Xianyou Cty, Dept Sci & Educ, 910,825 Main St, Licheng Town 351200, Putian, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 16期

关键词：

cancer risk; case-control; epidemiology; gastric cancer; SNP; GENETIC-VARIANTS; SUSCEPTIBILITY; RISK; PROLIFERATION; EPIDEMIOLOGY; ASSOCIATION; EXPRESSION; MIR-1297; INVASION;

D O I：

10.2217/bmm-2020-0003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aims:To explore new SNP sites of miRNAs associated with gastric cancer, thereby providing valuable biomarkers to diagnose and screen gastric cancer.Materials & methods:A 1:1 case-control study was carried out. Microarrays were used to screen the SNP loci of miRNAs in the genomes of matched pairs of patients, 96 with gastric cancer and 96 healthy controls. For validation, mass spectrometry was used to classify miRNA SNP loci in 622 pairs of subjects.Results:rs7143252 was linked to a higher occurrence of gastric cancer.Conclusions:These results suggest that rs7143252 could be used as a specific biomarker to diagnose and screen gastric cancer.

引用

页码：1565 / 1574

页数：10

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