Susceptibility of Virulent Yersinia pestis Bacteria to Predator Bacteria in the Lungs of Mice

被引:23
作者
Russo, Riccardo [1 ,2 ]
Kolesnikova, Irina [1 ,2 ]
Kim, Thomas [1 ,2 ]
Gupta, Shilpi [3 ]
Pericleous, Androulla [3 ]
Kadouri, Daniel E. [3 ]
Connell, Nancy D. [1 ,2 ,4 ]
机构
[1] Rutgers New Jersey Med Sch, Dept Med, Newark, NJ 07101 USA
[2] Rutgers New Jersey Med Sch, Ctr Emerging Pathogens, Newark, NJ 07101 USA
[3] Rutgers Sch Dent Med, Dept Oral Biol, Newark, NJ 07101 USA
[4] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Hlth Secur, Baltimore, MD 20102 USA
关键词
predatory bacteria; Bdellovibrio; Yersinia pestis; lung infection; select agent countermeasure; GRAM-NEGATIVE PATHOGENS; BDELLOVIBRIO-BACTERIOVORUS; MICAVIBRIO-AERUGINOSAVORUS; BIOLOGICAL WARFARE; RESISTANCE;
D O I
10.3390/microorganisms7010002
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Multi-drug resistant bacterial infections are a serious threat to global public health. Changes in treatment modalities and prudent use of antibiotics can assist in reducing the threat, but new approaches are also required for untreatable cases. The use of predatory bacteria, such as Bdellovibrio bacteriovorus, is among the novel approaches being considered as possible therapeutics for antibiotic resistant and/or unidentified bacterial infections. Previous studies have examined the feasibility of using predatory bacteria to reduce colony-forming units (CFUs) in the lungs of rats exposed to lethal doses of Klebsiella pneumoniae; here we apply the approach to the Tier 1 select agent Yersinia pestis, and show that three doses of B. bacteriovorus introduced every six hours reduces the number of CFUs of Y. pestis in the lungs of inoculated mice by 86% after 24 h of infection. These experiments further demonstrate that predatory bacteria may serve to combat Gram negative bacterial infections, including those considered potential bioweapon agents, in the future.
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页数:7
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