Regulation of mRNA stability in the nervous system and beyond

被引：39

作者：

Malter, JS ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53792 USA

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2001年 / 66卷 / 03期

关键词：

mRNA; mRNA decay; mRNA binding proteins; Alzheimer's disease; myelin; HuR;

D O I：

10.1002/jnr.10021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ability to control gene expression is central to normal development and function. For a growing number of genes in the central nervous system and peripheral tissues, expression is determined by changes in the rate of mRNA decay. At a molecular level, regulated interactions between the mRNA target and sequence-specific binding proteins either inhibit or accelerate decay, affording tight control over gene expression. This review discusses several examples of such posttranscriptional gene regulation. (C) 2001 Wiley-Liss, Inc.

引用

页码：311 / 316

页数：6

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