First Enantioselective Total Synthesis of (+)-(R)-Pinnatolide Using an Asymmetric Domino Allylation Reaction

被引：9

作者：

Tietze, Lutz F. ^{[1
]}

Wolfram, Thomas ^{[1
]}

Holstein, Julian J. ^{[2
]}

Dittrich, Birger ^{[2
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

[2] Univ Gottingen, Inst Inorgan Chem, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 16期

关键词：

FACIAL-SELECTIVE ALLYLATION; METHYL KETONES; DIASTEREOSELECTIVE ADDITION; HOMOALLYLIC ALCOHOLS; SECONDARY ALCOHOLS; REAGENTS; ALDEHYDES; ALLYLBORATION; ALLYLSILANES; REDUCTION;

D O I：

10.1021/ol301932d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient total synthesis of (+)-(R)-Pinnatolide is described. As a key step an asymmetric multicomponent domino allylation reaction of methyl levulinate is used to form the quaternary stereogenic center in a highly selective way.

引用

页码：4035 / 4037

页数：3

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