Asymmetric domino synthesis of indanes bearing four contiguous stereocentres catalyzed by sub-mol% loadings of a squaramide in minutes

被引：51

作者：

Loh, Charles C. J. ^{[1
]}

Hack, Daniel ^{[1
]}

Enders, Dieter ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 87期

基金：

欧洲研究理事会;

关键词：

MICHAEL-HENRY REACTION; HIGHLY STEREOSELECTIVE-SYNTHESIS; QUATERNARY STEREOCENTERS; 3-SUBSTITUTED OXINDOLES; CONJUGATE ADDITION; CASCADE REACTIONS; ENANTIOSELECTIVE SYNTHESIS; ORGANOCATALYSIS; DERIVATIVES; ACCESS;

D O I：

10.1039/c3cc46033a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient diastereo- and enantioselective synthesis of polyfunctionalized indanes bearing four contiguous stereogenic centres in generally very short reaction times and sub-mol% squaramide catalyst loadings has been developed. The novel methodology creates a maximum of two stereocentres per bond formation via an organocatalytic Michael-Henry domino reaction.

引用

页码：10230 / 10232

页数：3

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