Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

被引：360

作者：

Shigemoto-Mogami, Yukari ^{[1
]}

Hoshikawa, Kazue ^{[1
]}

Goldman, James E. ^{[2
]}

Sekino, Yuko ^{[1
]}

Sato, Kaoru ^{[1
]}

机构：

[1] Natl Inst Hlth Sci, Div Pharmacol, Neuropharmacol Lab, Tokyo 1588501, Japan

[2] Columbia Univ, Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY 10032 USA

来源：

JOURNAL OF NEUROSCIENCE | 2014年 / 34卷 / 06期

关键词：

cytokine; microglia; neurogenesis; neurosphere; oligodendrogenesis; subventricular zone; NEURAL PRECURSOR CELLS; NEURONAL DIFFERENTIATION; ADULT NEUROGENESIS; PROGENITOR CELLS; IFN-GAMMA; BRAIN; ACTIVATION; PROLIFERATION; CYTOKINES; INFLAMMATION;

D O I：

10.1523/JNEUROSCI.1619-13.2014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although microglia have long been considered as brain resident immune cells, increasing evidence suggests that they also have physiological roles in the development of the normal CNS. In this study, we found large numbers of activated microglia in the forebrain subventricular zone (SVZ) of the rat from P1 to P10. Pharmacological suppression of the activation, which produces a decrease in levels of a number of proinflammatory cytokines (i.e., IL-1 beta, IL-6, TNF-alpha, and IFN-gamma) significantly inhibited neurogenesis and oligodendrogenesis in the SVZ. In vitro neurosphere assays reproduced the enhancement of neurogenesis and oligodendrogenesis by activated microglia and showed that the cytokines revealed the effects complementarily. These results suggest that activated microglia accumulate in the early postnatal SVZ and that they enhance neurogenesis and oligodendrogenesis via released cytokines.

引用

页码：2231 / 2243

页数：13

共 66 条

[51] Interleukin-6, a mental cytokine [J].

Spooren, Anneleen ;

Kolmus, Krzysztof ;

Laureys, Guy ;

Clinckers, Ralph ;

De Keyser, Jacques ;

Haegeman, Guy ;

Gerlo, Sarah .

BRAIN RESEARCH REVIEWS, 2011, 67 (1-2) :157-183

[52]

Suzuki SO, 2003, J NEUROSCI, V23, P4240

[53] The development of neural stem cells [J].

Temple, S .

NATURE, 2001, 414 (6859) :112-117

[54] Long-Term Accumulation of Microglia with Proneurogenic Phenotype Concomitant with Persistent Neurogenesis in Adult Subventricular Zone After Stroke [J].

Thored, Par ;

Heldmann, Ursula ;

Gomes-Leal, Walace ;

Gisler, Ramiro ;

Darsalia, Vladimer ;

Taneera, Jalal ;

Nygren, Jens M. ;

Jacobsen, Sten-Eirik W. ;

Ekdahl, Christine T. ;

Kokaia, Zaal ;

Lindvall, Olle .

GLIA, 2009, 57 (08) :835-849

[55] Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia [J].

Tikka, T ;

Fiebich, BL ;

Goldsteins, G ;

Keinänen, R ;

Koistinaho, J .

JOURNAL OF NEUROSCIENCE, 2001, 21 (08) :2580-2588

[56] The Role of Microglia in the Healthy Brain [J].

Tremblay, Marie-Eve ;

Stevens, Beth ;

Sierra, Amanda ;

Wake, Hiroaki ;

Bessis, Alain ;

Nimmerjahn, Axel .

JOURNAL OF NEUROSCIENCE, 2011, 31 (45) :16064-16069

[57] Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells [J].

Vela, JM ;

Molina-Holgado, E ;

Arévalo-Martín, A ;

Almazán, G ;

Guaza, C .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2002, 20 (03) :489-502

[58] Microglia Modulate Hippocampal Neural Precursor Activity in Response to Exercise and Aging [J].

Vukovic, Jana ;

Colditz, Michael J. ;

Blackmore, Daniel G. ;

Ruitenberg, Marc J. ;

Bartlett, Perry F. .

JOURNAL OF NEUROSCIENCE, 2012, 32 (19) :6435-6443

[59] Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor [J].

Wagner, JP ;

Black, IB ;

DiCicco-Bloom, E .

JOURNAL OF NEUROSCIENCE, 1999, 19 (14) :6006-6016

[60] Microglia instruct subventricular zone neurogenesis [J].

Walton, Noah M. ;

Sutter, Benjamin M. ;

Laywell, Eric D. ;

Levkoff, Lindsay H. ;

Kearns, Sean M. ;

Marshall, Gregory P., II ;

Scheffler, Bjorn ;

Steindler, Dennis A. .

GLIA, 2006, 54 (08) :815-825

← 1 2 3 4 5 6 7 →