Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development

被引：145
作者：
Wang, Chi-Yun [1 ]
Lin, Chiou-Feng [1 ]
机构：
[1] Natl Cheng Kung Univ, Coll Med, Inst Clin Med, Tainan 701, Taiwan
来源：
DISEASE MARKERS | 2014年 / 2014卷
关键词：
TISSUE-PLASMINOGEN ACTIVATOR; PRIMER RECOGNITION PROTEINS; DOWN-REGULATION; PROSTATE-CANCER; DNA-REPLICATION; II EXPRESSION; T-PA; PROMOTES INVASION; CARCINOMA CELLS; LUNG-CARCINOMA;
D O I：
10.1155/2014/308976
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression. The structure of ANXA2 affects its cellular localization and function. However, posttranslational modification and protease-mediated N-terminal cleavage also play critical roles in regulating ANXA2. ANXA2 expression levels vary among different types of cancers. With some cancers, ANXA2 can be used for the detection and diagnosis of cancer and for monitoring cancer progression. ANXA2 is also required for drug-resistance. This review discusses the feasibility of ANXA2 which is active in cancer development and can be a therapeutic target in cancer management.
引用
收藏
页数：10
相关论文
共 108 条
[41]   Clinical significance of annexin II expression in human non-small cell lung cancer [J].
Jia, Jin-Wei ;
Li, Kun-Lin ;
Wu, Jin-Xing ;
Guo, Shu-Liang .
TUMOR BIOLOGY, 2013, 34 (03) :1767-1771
[42]   Immunohistochemical expression of Annexin A2 and S100A proteins in patients with bulky stage IB-IIA cervical cancer treated with neoadjuvant chemotherapy [J].
Jin, LanYing ;
Shen, Qi ;
Ding, Shengdi ;
Jiang, Wenxiao ;
Jiang, Lingling ;
Zhu, Xueqiong .
GYNECOLOGIC ONCOLOGY, 2012, 126 (01) :140-146
[43]   P36, THE MAJOR CYTOPLASMIC SUBSTRATE OF SRC TYROSINE PROTEIN-KINASE, BINDS TO ITS P11 REGULATORY SUBUNIT VIA A SHORT AMINO-TERMINAL AMPHIPHATIC HELIX [J].
JOHNSSON, N ;
MARRIOTT, G ;
WEBER, K .
EMBO JOURNAL, 1988, 7 (08) :2435-2442
[44]  
JOHNSTONE SA, 1992, J BIOL CHEM, V267, P25976
[45]   Characterization of the heparin binding properties of annexin II tetramer [J].
Kassam, G ;
Manro, A ;
Braat, CE ;
Louie, P ;
Fitzpatrick, SL ;
Waisman, DM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (24) :15093-15100
[46]   The p11 subunit of the annexin II tetramer plays a key role in the stimulation of t-PA-dependent plasminogen activation [J].
Kassam, G ;
Le, BH ;
Choi, KS ;
Kang, HM ;
Fitzpatrick, SL ;
Louie, P ;
Waisman, DM .
BIOCHEMISTRY, 1998, 37 (48) :16958-16966
[47]  
KUMBLE KD, 1992, J CELL SCI, V101, P35
[48]   Identification of the annexin A2 heterotetramer as a receptor for the plasmin-induced signaling in human peripheral monocytes [J].
Laumonnier, Y ;
Syrovets, T ;
Burysek, L ;
Simmet, T .
BLOOD, 2006, 107 (08) :3342-3349
[49]   Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo [J].
Ling, Q ;
Jacovina, AT ;
Deora, A ;
Febbraio, M ;
Simantov, R ;
Silverstein, RL ;
Hempstead, B ;
Mark, WH ;
Hajar, KA .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (01) :38-48
[50]  
Liu J., 2003, BMC BIOCH, V4
12345678910