Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development

被引：145

作者：

Wang, Chi-Yun ^{[1
]}

Lin, Chiou-Feng ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Inst Clin Med, Tainan 701, Taiwan

来源：

DISEASE MARKERS | 2014年 / 2014卷

关键词：

TISSUE-PLASMINOGEN ACTIVATOR; PRIMER RECOGNITION PROTEINS; DOWN-REGULATION; PROSTATE-CANCER; DNA-REPLICATION; II EXPRESSION; T-PA; PROMOTES INVASION; CARCINOMA CELLS; LUNG-CARCINOMA;

D O I：

10.1155/2014/308976

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression. The structure of ANXA2 affects its cellular localization and function. However, posttranslational modification and protease-mediated N-terminal cleavage also play critical roles in regulating ANXA2. ANXA2 expression levels vary among different types of cancers. With some cancers, ANXA2 can be used for the detection and diagnosis of cancer and for monitoring cancer progression. ANXA2 is also required for drug-resistance. This review discusses the feasibility of ANXA2 which is active in cancer development and can be a therapeutic target in cancer management.

引用

页数：10

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