Molecular magnetic resonance imaging in cancer

被引：69

作者：

Haris, Mohammad ^{[1
]}

Yadav, Santosh K. ^{[1
]}

Rizwan, Arshi ^{[2
]}

Singh, Anup ^{[3
]}

Wang, Ena ^{[1
]}

Hariharan, Hari ^{[4
]}

Reddy, Ravinder ^{[4
]}

Marincola, Francesco M. ^{[1
]}

机构：

[1] Sidra Med & Res Ctr, Doha 26999, Qatar

[2] All India Inst Med Sci, New Delhi, India

[3] Indian Inst Technol, Ctr Biomed Engn, Delhi, India

[4] Univ Penn, Dept Radiol, Ctr Magnet Resonance & Opt Imaging, Philadelphia, PA 19104 USA

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2015年 / 13卷

关键词：

Cancer; Magnetic resonance imaging; Magnetic resonance spectroscopy; Hyperpolarization; Chemical exchange saturation transfer (CEST) imaging; Reporter genes; Cancer immunotherapy; PROTON MR SPECTROSCOPY; CHOLINE PHOSPHOLIPID-METABOLISM; HUMAN BREAST-CANCER; DECOUPLED P-31 MRS; HUMAN BRAIN-TUMORS; IN-VIVO; PROSTATE-CANCER; COLORECTAL-CANCER; GENE-EXPRESSION; LUNG-CANCER;

D O I：

10.1186/s12967-015-0659-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The ability to identify key biomolecules and molecular changes associated with cancer malignancy and the capacity to monitor the therapeutic outcome against these targets is critically important for cancer treatment. Recent developments in molecular imaging based on magnetic resonance (MR) techniques have provided researchers and clinicians with new tools to improve most facets of cancer care. Molecular imaging is broadly described as imaging techniques used to detect molecular signature at the cellular and gene expression levels. This article reviews both established and emerging molecular MR techniques in oncology and discusses the potential of these techniques in improving the clinical cancer care. It also discusses how molecular MR, in conjunction with other structural and functional MR imaging techniques, paves the way for developing tailored treatment strategies to enhance cancer care.

引用

页数：16

共 118 条

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