Development of Solid-Supported Glaser-Hay Couplings

被引：14

作者：

Tripp, Valerie T. ^{[1
]}

Lampkowski, Jessica S. ^{[1
]}

Tyler, Ryan ^{[1
]}

Young, Douglas D. ^{[1
]}

机构：

[1] Coll William & Mary, Dept Chem, Williamsburg, VA 23187 USA

来源：

ACS COMBINATORIAL SCIENCE | 2014年 / 16卷 / 04期

关键词：

solid-phase synthesis; Glaser-Hay coupling; chemoselectivity; polyynes; TERMINAL ALKYNES;

D O I：

10.1021/co500018k

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

While the Glaser-Hay coupling of terminal alkynes is a useful reaction, several issues associated with chemoselectivity preclude its widespread application in synthetic chemistry. To address these issues, a solid-supported Glaser Hay methodology was developed to afford only asymmetric diyne products. This methodology was then applied to a series of immobilized alkynes with a diverse set of soluble allcynes to generate an array of heterocoupled products in high yields and purities.

引用

页码：164 / 167

页数：4

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