Is Disease Activity in Rheumatoid Arthritis during Pregnancy and after Delivery Predictive for Disease Activity in a Subsequent Pregnancy?

被引：8

作者：

Ince-Askan, Hilal ^{[1
]}

Hazes, Johanna M. W. ^{[1
]}

Dolhain, Radboud J. E. M. ^{[1
]}

机构：

[1] Erasmus MC, Dept Rheumatol, NL-3000 CA Rotterdam, Netherlands

来源：

JOURNAL OF RHEUMATOLOGY | 2016年 / 43卷 / 01期

关键词：

RHEUMATOID ARTHRITIS; DISEASE ACTIVITY; PREGNANCY; ASSOCIATION; NATIONWIDE;

D O I：

10.3899/jrheum.150565

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To determine whether disease activity in women with rheumatoid arthritis (RA) in 1 pregnancy is predictive for disease activity in a subsequent pregnancy. Methods. In the Pregnancy-induced Amelioration of Rheumatoid Arthritis study, there are prospective data on 27 patients who participated twice. Improvement and deterioration is determined by changes in the Disease Activity Score in 28 joints. Results. Only 4 patients (14.8%) had comparable disease courses in both pregnancies, whereas treatment remained mostly similar. In contrast, a flare postpartum after the first pregnancy was predictive for a flare after the second pregnancy (p = 0.003). Conclusion. RA disease course in following pregnancies cannot be predicted based upon previous pregnancies. However, a flare postpartum seems to predict subsequent flares.

引用

页码：22 / 25

页数：4

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