Evolving Boolean regulatory networks with epigenetic control

被引：6
|
作者：
Bull, Larry [1 ]
机构：
[1] Univ W England, Dept Comp Sci & Creat Technol, Bristol BS16 1QY, Avon, England
来源：
BIOSYSTEMS | 2014年 / 116卷
关键词：
Development; Dynamical systems; Methylation; Multicellularity; RBNK model; STABILITY;
D O I：
10.1016/j.biosystems.2013.12.004
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The significant role of epigenetic mechanisms within natural systems has become increasingly clear. This paper uses a recently presented abstract, tunable Boolean genetic regulatory network model to explore aspects of epigenetics. It is shown how dynamically controlling transcription via a DNA methylation-inspired mechanism can be selected for by simulated evolution under various single and multicellular scenarios. Further, it is shown that the effects of such control can be inherited without detriment to fitness. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：36 / 42
页数：7
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