Possible artemisinin-based combination therapy-resistant malaria in Nigeria: a report of three cases

被引：24

作者：

Ajayi, Nnennaya Anthony ^{[1
]}

Ukwaja, Kingsley Nnanna ^{[1
]}

机构：

[1] Fed Teaching Hosp Abakaliki, Dept Internal Med, Abakaliki 23433, Ebonyi State, Nigeria

来源：

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2013年 / 46卷 / 04期

关键词：

Malaria; Artemisinin-based combination therapy; Artemether-lumefantrine; Early treatment failure; Resistance; Nigeria; PLASMODIUM-FALCIPARUM MALARIA; ARTEMETHER-LUMEFANTRINE; TREATMENT FAILURE; TRAVELER;

D O I：

10.1590/0037-8682-0098-2013

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Artemisinin-based combination therapy-resistant malaria is rare in Sub-Saharan Africa. The World Health Organization identifies monitoring and surveillance using day-3 parasitaemia post-treatment as the standard test for identifying suspected artemisinin resistance. We report three cases of early treatment failure due to possible artemisinin-based combination therapy-resistant Plasmodium falciparum malaria. All cases showed adequate clinical and parasitological responses to quinine. This study reveals a need to re-evaluate the quality and efficacy of artemisinin-based combination therapy agents in Nigeria and Sub-Saharan Africa.

引用

页码：525 / 527

页数：3

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