A hyperactive postprandial response in the neorectum - the clue to low anterior resection syndrome after total mesorectal excision surgery?

被引：59

作者：

Emmertsen, K. J. ^{[1
]}

Bregendahl, S. ^{[1
]}

Fassov, J. ^{[2
]}

Krogh, K. ^{[2
]}

Laurberg, S. ^{[1
]}

机构：

[1] Aarhus Univ Hosp, Dept Colorectal Surg, Surg Res Unit, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ Hosp, Dept Hepatol & Gastroenterol 5, Neurogastroenterol Unit, DK-8000 Aarhus C, Denmark

来源：

COLORECTAL DISEASE | 2013年 / 15卷 / 10期

关键词：

Rectal cancer; LARS; postprandial response; pathophysiology; anal manometry; multimodal rectal stimulation; AUTONOMIC NERVE PRESERVATION; RECTAL-CANCER; ANAL-SPHINCTER; ANASTOMOSIS; DENERVATION; MANOMETRY; CARCINOMA; DISORDER; RECOVERY; MOTILITY;

D O I：

10.1111/codi.12360

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AimTo investigate neorectal properties regarding biomechanical, sensory and postprandial response in patients after total mesorectal excision without neoadjuvant radiotherapy in groups of no low anterior resection syndrome (LARS) patients and major LARS patients. MethodPatients without LARS (n=9) and patients with major LARS (n=23) were investigated by multimodal rectal stimulation and standard anorectal physiological tests, and results were compared. ResultsPatients with major LARS had an increased postprandial response with a significant increase in pressure in the neorectum after a meal compared with patients without LARS (P=0.017). No biomechanical differences could be detected. ConclusionLow anterior resection syndrome seems to be caused by physiological changes due to neural damage more than structural changes in the ano-neorectum.

引用

页码：e599 / e606

页数：8

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