Somatostatin receptor imaging of non-small cell lung cancer with 99mTc depreotide

被引：74
作者：
Menda, Y
Kahn, D
机构：
[1] Univ Iowa, Coll Med, Div Nucl Med, Iowa City, IA USA
[2] Vet Affairs Med Ctr, Iowa City, IA 52242 USA
来源：
SEMINARS IN NUCLEAR MEDICINE | 2002年 / 32卷 / 02期
关键词：
D O I：
10.1053/snuc.2002.31564
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Several tumors overexpress somatostatin receptors (SSTR) and can thus be imaged with radiolabeled analogues of somatostatin. Tc-99m depreotide is a new radiolabeled somatostatin analogue that shows high affinity for SSTR2, SSTR3, and SSTR5 subtypes. It has been recently FDA-approved for use in the evaluation of indeterminate solitary pulmonary nodules. SPECT with Tc-99m depreotide is highly accurate in this clinical setting and may be preferable to FDG-PET because of its lower cost and wider availability. Large studies are also underway to evaluate the accuracy of Tc-99m depreotide in staging of lung cancer. Copyright 2002, Elsevier Science (USA). All rights reserved.
引用
收藏
页码：92 / 96
页数：5
相关论文
共 13 条
[1]  
Berkowitz M, 2001, J NUCL MED, V42, p28P
[2]   A multicenter trial with a somatostatin analog 99mTc depreotide in the evaluation of solitary pulmonary nodules [J].
Blum, J ;
Handmaker, H ;
Lister-James, J ;
Rinne, N .
CHEST, 2000, 117 (05) :1232-1238
[3]   The utility of a somatostatin-type receptor binding peptide radiopharmaceutical (P829) in the evaluation of solitary pulmonary nodules [J].
Blum, JE ;
Handmaker, H ;
Rinne, NA .
CHEST, 1999, 115 (01) :224-232
[4]   GENE-EXPRESSION OF SOMATOSTATIN RECEPTOR SUBTYPES, SSTR1 AND SSTR2, IN HUMAN LUNG-CANCER CELL-LINES [J].
FUJITA, T ;
YAMAJI, Y ;
SATO, M ;
MURAO, K ;
TAKAHARA, J .
LIFE SCIENCES, 1994, 55 (23) :1797-1806
[5]   Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions - A meta-analysis [J].
Gould, MK ;
Maclean, CC ;
Kuschner, WG ;
Rydzak, CE ;
Owens, DK .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (07) :914-924
[6]  
KERNSTINE KH, 2001, AM SOC CLIN ONCOLOGY, V20, pA339
[7]  
KWEKKEBOOM DJ, 1994, EUR J NUCL MED, V21, P1106
[8]  
LISTERJAMES J, 1994, J NUCL MED, V35, pP257
[9]  
Menda Y, 2001, J NUCL MED, V42, p304P
[10]   Somatostatin receptors and their subtypes in human tumors and in peritumoral vessels [J].
Reubi, JC ;
Schaer, JC ;
Laissue, JA ;
Waser, B .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1996, 45 (08) :39-41
12