Insight into the metabolic mechanism of scoparone on biomarkers for inhibiting Yanghuang syndrome

被引：49

作者：

Fang, Heng ^{[1
]}

Zhang, Aihua ^{[1
]}

Yu, Jingbo ^{[1
]}

Wang, Liang ^{[1
]}

Liu, Chang ^{[1
]}

Zhou, Xiaohang ^{[1
]}

Sun, Hui ^{[1
]}

Song, Qi ^{[1
]}

Wang, Xijun ^{[1
,2
]}

机构：

[1] Heilongjiang Univ Chinese Med, Lab Metabol, Dept Pharmaceut Anal,Chinmed Res Ctr,TCM State Ad, Natl TCM Key Lab Serum Pharmacochem,Sino Amer Chi, Heping Rd 24, Harbin 150040, Peoples R China

[2] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Ave Wai Long, Taipa, Macau, Peoples R China

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

黑龙江省自然科学基金;

关键词：

SPECTROMETRY; CLEARANCE; JAUNDICE; FAILURE; GENE;

D O I：

10.1038/srep37519

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Scoparone (6,7-dimethoxycoumarin) is the representative ingredient of Yinchenhao (Artemisia capillaris Thunb.) which is a famous Chinese medicinal herb and shows favorable efficacy for all kinds of liver disease, specifically for the treatment of Yanghuang syndrome (YHS). The precise molecular mechanism concerning the action of scoparone on YHS is yet to be fully elucidated. The aim of the present study was to determine the mechanism of scoparone and evaluate its efficacy on metabolite levels. The differential expression of metabolites responsible for the pharmacological effects of scoparone was characterized and the protection effect of scoparone against this disease. Using multivariate statistical analysis, 33 biomarkers were identified using precise MS/MS and play an important role in the regulation of key metabolic pathways associated with liver disease. In addition, pathological results also showed consistent changes in the YHS model group and after treatment with scoparone, both the metabolic profile and histopathology resembled that of normal level, which suggesting favorable efficacy over the observed time period. The present work indicated that a metabolomics platform provided a new insight into understanding the mechanisms of action of natural medicines such as scoparone.

引用

页数：9

共 33 条

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