Cancer-associated fibroblasts in pancreatic adenocarcinoma

被引：2
|
作者：
Pan, Boju [1 ,2 ]
Liao, Quan [1 ,2 ]
Niu, Zheyu [1 ,2 ]
Zhou, Li [1 ,2 ]
Zhao, Yupei [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Dept Gen Surg, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China
[2] Peking Union, Coll Med, Beijing 100730, Peoples R China
来源：
FUTURE ONCOLOGY | 2015年 / 11卷 / 18期
关键词：
CAFs; chemotherapy; CXCL12; pancreatic ductal adenocarcinoma; SPARC; ACTIVATION PROTEIN; SPARC EXPRESSION; RETINOIC ACID; PLASMINOGEN-ACTIVATOR; NAB-PACLITAXEL; STELLATE CELLS; GEMCITABINE; ANGIOGENESIS; RECEPTOR; PROLIFERATION;
D O I：
10.2217/fon.15.176
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is one of the most highly malignant tumors with a very poor prognosis. In addition to the cancer cells, the stroma of tumor can expand by 50% and influence cancer cell growth. Cancer-associated fibroblasts (CAFs) are important components of tumor stroma. Cancer cells, normal fibroblasts, normal epithelial cells as well as bone marrow-derived myofibroblasts contribute to the emergence of CAFs through various cytokines (e.g., TGF-, SHH, PDGF) and epithelial-to-mesenchymal transition. CAFs affect cancer growth, survival, metastasis, angiogenesis and immunosurveillance through the secretion of various cytokines, such as CXCL12 and secreted protein acidic and rich in cystein. Also, CAFs correlate to the prognosis and chemoresistance of PDAC patients. As novel therapeutic targets, CAFs, and their relative factors, represent an important role in PDAC therapy.
引用
收藏
页码：2603 / 2610
页数：8
相关论文
共 50 条
  • [31] Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma
    Neuzillet, Cindy
    Tijeras-Raballand, Annemilai
    Ragulan, Chanthirika
    Cros, Jerome
    Patil, Yatish
    Martinet, Matthieu
    Erkan, Mert
    Kleeff, Joerg
    Wilson, Jeremy
    Apte, Minoti
    Tosolini, Marie
    Wilson, Abigail S.
    Delvecchio, Francesca R.
    Bousquet, Corinne
    Paradis, Valerie
    Hammel, Pascal
    Sadanandam, Anguraj
    Kocher, Hemant M.
    JOURNAL OF PATHOLOGY, 2019, 248 (01) : 51 - 65
  • [32] Spatial and phenotypic characterization of pancreatic cancer-associated fibroblasts after neoadjuvant treatment
    Nielsen, Michael Friberg Bruun
    Mortensen, Michael Bau
    Sorensen, Mia Dahl
    Wirenfeldt, Martin
    Kristensen, Bjarne Winther
    Schroder, Henrik Daa
    Pteiffer, Per
    Detlefsen, Sonke
    HISTOLOGY AND HISTOPATHOLOGY, 2020, 35 (08) : 811 - 825
  • [33] Heterogeneity of Cancer-Associated Fibroblasts and the Tumor Immune Microenvironment in Pancreatic Cancer
    Shinkawa, Tomohiko
    Ohuchida, Kenoki
    Nakamura, Masafumi
    CANCERS, 2022, 14 (16)
  • [34] The multi-faceted roles of cancer-associated fibroblasts in pancreatic cancer
    Kwon, John Y.
    Vera, Renzo E.
    Fernandez-Zapico, Martin E.
    CELLULAR SIGNALLING, 2025, 127
  • [35] Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations
    Nielsen, Michael Friberg Bruun
    Mortensen, Michael Bau
    Detlefsen, Sonke
    WORLD JOURNAL OF GASTROENTEROLOGY, 2018, 24 (41) : 4663 - 4678
  • [36] Metastatic Transition of Pancreatic Ductal Cell Adenocarcinoma Is Accompanied by the Emergence of Pro-Invasive Cancer-Associated Fibroblasts
    Liu, Shaofei
    Suhail, Yasir
    Novin, Ashkan
    Perpetua, Lorrie
    Kshitiz
    CANCERS, 2022, 14 (09)
  • [37] Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts
    Ishii, Norihiro
    Araki, Kenichiro
    Yokobori, Takehiko
    Hagiwara, Kei
    Gantumur, Dorgormaa
    Yamanaka, Takahiro
    Handa, Tadashi
    Tsukagoshi, Mariko
    Igarashi, Takamichi
    Watanabe, Akira
    Kubo, Norio
    Harimoto, Norifumi
    Masamune, Atsushi
    Umezawa, Kazuo
    Kuwano, Hiroyuki
    Shirabe, Ken
    CANCER SCIENCE, 2019, 110 (01) : 334 - 344
  • [38] Quantitative proteomic profiling of primary cancer-associated fibroblasts in oesophageal adenocarcinoma
    Manousopoulou, Antigoni
    Hayden, Annette
    Mellone, Massimiliano
    Garay-Baquero, Diana J.
    White, Cory H.
    Noble, Fergus
    Lopez, Monette
    Thomas, Gareth J.
    Underwood, Timothy J.
    Garbis, Spiros D.
    BRITISH JOURNAL OF CANCER, 2018, 118 (09) : 1200 - 1207
  • [39] Proteomes of Extracellular Vesicles From Pancreatic Cancer Cells and Cancer-Associated Fibroblasts
    Pan, Sharon
    Lai, Lisa A.
    Simeone, Diane M. M.
    Dawson, David W. W.
    Yan, Yuanqing
    Crnogorac-Jurcevic, Tatjana
    Chen, Ru
    Brentnall, Teresa A.
    PANCREAS, 2022, 51 (07) : 790 - 799
  • [40] Heterogeneous cancer-associated fibroblasts: A new perspective for understanding immunosuppression in pancreatic cancer
    Zhang, Zhilin
    Zhang, Huan
    Shi, Lin
    Wang, Daorong
    Tang, Dong
    IMMUNOLOGY, 2022, 167 (01) : 1 - 14
12345