Human chorionic gonadotropin (hCG) regulation of galectin-3 expression in endometrial epithelial cells and endometrial stromal cells

被引：21

作者：

Yang, Huan ^{[1
]}

Lei, Cai Xia ^{[2
]}

Zhang, Wei ^{[1
]}

机构：

[1] Fudan Univ, Obstet & Gynecol Hosp, Shanghai 200011, Peoples R China

[2] Shanghai Ji Ai Genet & IVF China USA Ctr, Shanghai 200011, Peoples R China

来源：

ACTA HISTOCHEMICA | 2013年 / 115卷 / 01期

关键词：

Galectin-3; hCG; Endometrium; UTERINE RECEPTIVITY; HUMAN BLASTOCYST; TROPHOBLAST; APOPTOSIS; ADHESION; DECIDUA; MARKERS; GROWTH;

D O I：

10.1016/j.acthis.2011.05.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Previous investigations on galectin-3 (gal-3) have focused mainly on its role in some malignant tumors. It was believed that gal-3 plays important roles in cell proliferation, apoptosis and adhesion in many cell types. Recently, gal-3 has been recognized as a factor related to endometrial receptivity in the human endometrium and trophoblast during embryo implantation. Human chorionic gonadotropin (hCG) is a specific embryonic hormone providing a signal from the embryo involved in preparing the receptive endometrium for embryo implantation. The current study aimed to determine whether hCG regulates gal-3 expression in endometrial cells. Our results showed that expression of gal-3 in both endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) could be regulated by hCG in an intricate manner. These results indicate that gal-3 might be regulated by hCG in preparing the endometrium for embryonic implantation. (C) 2011 Elsevier GmbH. All rights reserved.

引用

页码：3 / 7

页数：5