Working memory load modulation of parieto-frontal connections: Evidence from dynamic causal modeling

被引:72
作者
Ma, Liangsuo [1 ]
Steinberg, Joel L. [1 ]
Hasan, Khader M. [2 ]
Narayana, Ponnada A. [2 ]
Kramer, Larry A. [2 ]
Moeller, F. Gerard [1 ]
机构
[1] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77054 USA
[2] Univ Texas Hlth Sci Ctr, Dept Diagnost & Intervent Imaging, Houston, TX USA
关键词
DCM; dynamic causal modeling; effective connectivity; working memory; working memory load; IMT; DMT; ANTERIOR CINGULATE CORTEX; SHORT-TERM-MEMORY; LEFT PREFRONTAL CORTEX; TOP-DOWN MODULATION; POSTERIOR PARIETAL; BRAIN-REGIONS; FUNCTIONAL CONNECTIVITY; FRONTOPARIETAL NETWORK; CORTICAL INTERACTIONS; GRANGER CAUSALITY;
D O I
10.1002/hbm.21329
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Previous neuroimaging studies have shown that working memory load has marked effects on regional neural activation. However, the mechanism through which working memory load modulates brain connectivity is still unclear. In this study, this issue was addressed using dynamic causal modeling (DCM) based on functional magnetic resonance imaging (fMRI) data. Eighteen normal healthy subjects were scanned while they performed a working memory task with variable memory load, as parameterized by two levels of memory delay and three levels of digit load (number of digits presented in each visual stimulus). Eight regions of interest, i.e., bilateral middle frontal gyrus (MFG), anterior cingulate cortex (ACC), inferior frontal cortex (IFC), and posterior parietal cortex (PPC), were chosen for DCM analyses. Analysis of the behavioral data during the fMRI scan revealed that accuracy decreased as digit load increased. Bayesian inference on model structure indicated that a bilinear DCM in which memory delay was the driving input to bilateral PPC and in which digit load modulated several parieto-frontal connections was the optimal model. Analysis of model parameters showed that higher digit load enhanced connection from L PPC to L IFC, and lower digit load inhibited connection from R PPC to L ACC. These findings suggest that working memory load modulates brain connectivity in a parieto-frontal network, and may reflect altered neuronal processes, e.g., information processing or error monitoring, with the change in working memory load. Hum Brain Mapp, 2012. (c) 2011 Wiley Periodicals, Inc
引用
收藏
页码:1850 / 1867
页数:18
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