Attachment of adeno-associated virus type 3H to fibroblast growth factor receptor 1

被引：39
作者：
Blackburn, SD [1 ]
Steadman, RA [1 ]
Johnson, FB [1 ]
机构：
[1] Brigham Young Univ, Dept Mol Biol & Microbiol, Provo, UT 84602 USA
来源：
ARCHIVES OF VIROLOGY | 2006年 / 151卷 / 03期
关键词：
D O I：
10.1007/s00705-005-0650-6
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Heparan sulfate proteoglycan is thought to act as primary receptor for adeno-associated virus type 2 (AAV-2). Reported coreceptors include alpha V beta 5 integrin, fibroblast growth factor receptor 1 (FGFR-1), and hepatocyte growth factor (c-Met). The interaction of AAV type 3 (AAV-3) with possible cell membrane receptors is incompletely defined. In this study, using assays detecting competition with viral infection, virus binding inhibition assays and dot blotting, we show attachment of AAV-3 strain H to heparin, heparan sulfate, and FGFR-1. These findings provide new information on the possible receptor array used by AAV-3.
引用
收藏
页码：617 / 623
页数：7
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