Synergistic Wound Healing by Novel Ag@ZIF-8 Nanostructures

被引：44
作者：
Barjasteh, Mahdi [1 ]
Dehnavi, Seyed Mohsen [2 ]
Seyedkhani, Shahab Ahmadi [1 ,3 ]
Rahnamaee, Seyed Yahya [4 ]
Golizadeh, Mortaza [5 ]
机构：
[1] Sharif Univ Technol, Inst Nanosci & Nanotechnol INST, POB 14588-89694, Tehran, Iran
[2] Shahid Beheshti Univ, Fac Life Sci & Biotechnol, Mol Biol, POB 19839-69411, Tehran, Iran
[3] Sharif Dev Hlth & Biotechnol Inst, BioTex Innovat Factory, POB 14587-53851, Tehran, Iran
[4] Sharif Univ Technol, Dept Mat Sci & Engn, Polymer Mat Res Grp PMRG, POB 14588-89694, Tehran, Iran
[5] Sharif Univ Technol, Dept Chem & Petr Engn, POB 14588-89694, Tehran, Iran
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2022年 / 629卷
关键词：
Wound Dressing; Silver; ZIF-8; Chitosan; Bacterial Cellulose; ANTIBACTERIAL ACTIVITY; ELECTROSPUN NANOFIBERS; SILVER NANOPARTICLES; CHITOSAN; ZIF-8; BIOCOMPATIBILITY; FIBROBLASTS; FRAMEWORKS; SCAFFOLDS; MEMBRANES;
D O I：
10.1016/j.ijpharm.2022.122339
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this paper, novel zeolitic imidazolate framework-8 (ZIF-8) functionalized with Ag (Ag@ZIF-8) nanoparticles were synthesized through a green, facile and environmental-friendly process for wound dressing applications. X-ray diffraction revealed that the ZIF-8 and Ag@ZIF-8 were successfully synthesized by green solvents at ambient temperature. Field-emission scanning electron microscopy indicated a homogeneous porous blend of-30 nm chitosan/bacterial cellulose (CS/BC) nanofibers embedded with-80-110 nm nanoparticles of the ZIF-8 and Ag@ZIF-8. Transmission electron microscopy revealed the Ag@ZIF-8 nanostructures consist of ZIF-8 cores that are covered by 5-20 nm Ag nanoparticles. MTT assay indicated excellent cell viability values of-115 and 109% for the CS/BC nanocomposites reinforced by ZIF-8 and Ag@ZIF-8 nanoparticles, respectively. The Ag-containing wound dressings showed 52-300% of effective antibacterial activities. Animal studies demonstrated excellent healing for the wound treated by CS/BC-25%Ag@ZIF-8 nanocomposite with-91% of wound closure after 14 days of treatment. Hematoxylin and eosin (H&E) staining revealed successful healing and tissue regeneration for the wounds treated using the CS/BC-Ag@ZIF-8 nanocomposites. This kind of nanocomposites with synergistic antimicrobial and bioactivity properties can be a promising candidate for regenerative medicine.
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页数：14
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