Variable expression patterns of Mycobacterium tuberculosis PE-PGRS genes:: Evidence that PE-PGRS16 and PE-PGRS26 are inversely regulated in vivo

被引：56

作者：

Dheenadhayalan, Veerabadran

Delogu, Giovanni

Sanguinetti, Maurizio

Fadda, Giovanni

Brennan, Michael J.

机构：

[1] US FDA, Off Vaccines Res & Review, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

[2] Univ Sacred Heart, Inst Microbiol, Rome, Italy

来源：

JOURNAL OF BACTERIOLOGY | 2006年 / 188卷 / 10期

关键词：

D O I：

10.1128/JB.188.10.3721-3725.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Evaluation of expression of 16 PE-PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.

引用

页码：3721 / 3725

页数：5

共 25 条

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