Fabrication of a Microneedle/CNT Hierarchical Micro/Nano Surface Electrochemical Sensor and Its In-Vitro Glucose Sensing Characterization

被引:69
作者
Yoon, Youngsam [1 ]
Lee, Gil S. [1 ]
Yoo, Koangki [2 ]
Lee, Jeong-Bong [1 ]
机构
[1] Univ Texas Dallas, Dept Elect Engn, Richardson, TX 75080 USA
[2] Hanbat Natl Univ, Dept Informat & Commun Engn, Taejon 305719, South Korea
关键词
NANOPARTICLES;
D O I
10.3390/s131216672
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
We report fabrication of a microneedle-based three-electrode integrated electrochemical sensor and in-vitro characterization of this sensor for glucose sensing applications. A piece of silicon was sequentially dry and wet etched to form a 15 × 15 array of tall (approximately 380 μm) sharp silicon microneedles. Iron catalyst was deposited through a SU-8 shadow mask to form the working electrode and counter electrode. A multi-walled carbon nanotube forest was grown directly on the silicon microneedle array and platinum nano-particles were electrodeposited. Silver was deposited on the Si microneedle array through another shadow mask and chlorinated to form a Ag/AgCl reference electrode. The 3-electrode electrochemical sensor was tested for various glucose concentrations in the range of 3~20 mM in 0.01 M phosphate buffered saline (PBS) solution. The sensor's amperometric response to the glucose concentration is linear and its sensitivity was found to be 17.73 ± 3 μA/mM-cm2. This microneedle-based sensor has a potential to be used for painless diabetes testing applications. © 2013 by the authors; licensee MDPI, Basel, Switzerland.
引用
收藏
页码:16672 / 16681
页数:10
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