Multipurpose heterofunctional dendritic scaffolds as crosslinkers towards functional soft hydrogels and implant adhesives in bone fracture applications

被引：15

作者：

Hed, Yvonne ^{[1
]}

Oberg, Kim ^{[1
]}

Berg, Sandra ^{[1
]}

Nordberg, Axel ^{[1
,2
]}

von Holst, Hans ^{[2
]}

Malkoch, Michael ^{[1
]}

机构：

[1] KTH Royal Inst Technol Polymer & Fiber Technol, Div Coating Technol, Stockholm, Sweden

[2] KTH Royal Inst Technol, Sch Technol & Hlth, Div Neuron Engn, Stockholm, Sweden

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2013年 / 1卷 / 44期

基金：

瑞典研究理事会;

关键词：

THIOL-ENE; BIFUNCTIONAL DENDRIMERS; CLICK CHEMISTRY; NETWORKS; FIXATION; ROBUST; FIBER;

D O I：

10.1039/c3tb21061h

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Two sets of heterofunctional dendritic frameworks displaying an inversed and exact number of ene and azide groups have successfully been synthesized and post-functionalized with biorelevant molecules. Their facile scaffolding ability enabled the fabrication of soft and azide functional dendritic hydrogels with modulus close to muscle tissue. The dendritic scaffolds are furthermore shown to be promising primers for the development of novel bone fracture stabilization adhesives with shear strengths succeeding commercial Histroacryl (R).

引用

页码：6015 / 6019

页数：5

共 40 条

[1] Enhanced Bioactivity of Internally Functionalized Cationic Dendrimers with PEG Cores [J].

Albertazzi, Lorenzo ;

Mickler, Frauke M. ;

Pavan, Giovanni M. ;

Salomone, Fabrizio ;

Bardi, Giuseppe ;

Panniello, Mariangela ;

Amir, Elizabeth ;

Kang, Taegon ;

Killops, Kato L. ;

Braeuchle, Christoph ;

Amir, Roey J. ;

Hawker, Craig J. .

BIOMACROMOLECULES, 2012, 13 (12) :4089-4097

[2] Multifunctional Trackable Dendritic Scaffolds and Delivery Agents [J].

Amir, Roey J. ;

Albertazzi, Lorenzo ;

Willis, Jenny ;

Khan, Anzar ;

Kang, Taegon ;

Hawker, Craig J. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (15) :3425-3429

[3] Pushing the Limits for Thiol-Ene and CuAAC Reactions: Synthesis of a 6th Generation Dendrimer in a Single Day [J].

Antoni, Per ;

Robb, Maxwell J. ;

Campos, Luis ;

Montanez, Maria ;

Hult, Anders ;

Malmstrom, Eva ;

Malkoch, Michael ;

Hawker, Craig J. .

MACROMOLECULES, 2010, 43 (16) :6625-6631

[4] Bifunctional Dendrimers: From Robust Synthesis and Accelerated One-Pot Postfunctionalization Strategy to Potential Applications [J].

Antoni, Per ;

Hed, Yvonne ;

Nordberg, Axel ;

Nystrom, Daniel ;

von Holst, Hans ;

Hult, Anders ;

Malkoch, Michael .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (12) :2126-2130

[5] Bioorthogonal Click Chemistry: An Indispensable Tool to Create Multifaceted Cell Culture Scaffolds [J].

Azagarsamy, Malar A. ;

Anseth, Kristi S. .

ACS MACRO LETTERS, 2013, 2 (01) :5-9

[6]

Braese S., 2010, Organic Azides: Syntheses and Applications

[7] Cytocompatibility of UV and visible light photoinitiating systems on cultured NIH/3T3 fibroblasts in vitro [J].

Bryant, SJ ;

Nuttelman, CR ;

Anseth, KS .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2000, 11 (05) :439-457

[8] Cell adhesion on an artificial extracellular matrix using aptamer-functionalized PEG hydrogels [J].

Chen, Niancao ;

Zhang, Zhaoyang ;

Soontornworajit, Boonchoy ;

Zhou, Jing ;

Wang, Yong .

BIOMATERIALS, 2012, 33 (05) :1353-1362

[9] Tissues and bone adhesives - historical aspects [J].

Donkerwolcke, M ;

Burny, F ;

Muster, D .

BIOMATERIALS, 1998, 19 (16) :1461-1466

[10] Matrix elasticity directs stem cell lineage specification [J].

Engler, Adam J. ;

Sen, Shamik ;

Sweeney, H. Lee ;

Discher, Dennis E. .

CELL, 2006, 126 (04) :677-689

← 1 2 3 4 →