Dispersion Method for Safety Research on Manufactured Nanomaterials

被引：37

作者：

Wu, Wenting ^{[1
,2
]}

Ichihara, Gaku ^{[1
]}

Suzuki, Yuka ^{[2
]}

Izuoka, Kiyora ^{[2
]}

Oikawa-Tada, Saeko ^{[2
]}

Chang, Jie ^{[1
,2
]}

Sakai, Kiyoshi ^{[3
]}

Miyazawa, Kunichi ^{[4
]}

Porter, Dale ^{[5
]}

Castranova, Vincent ^{[5
]}

Kawaguchi, Masami ^{[6
]}

Ichihara, Sahoko ^{[2
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Environm & Occupat Hlth, Nagoya, Aichi 4648601, Japan

[2] Mie Univ, Grad Sch Reg Innovat Studies, Tsu, Mie, Japan

[3] Nagoya City Publ Hlth Res Inst, Nagoya, Aichi, Japan

[4] Natl Inst Mat Sci, Tsukuba, Ibaraki 3050047, Japan

[5] NIOSH, Washington, DC USA

[6] Mie Univ, Grad Sch Engn, Div Chem Mat, Tsu, Mie, Japan

来源：

INDUSTRIAL HEALTH | 2014年 / 52卷 / 01期

基金：

日本学术振兴会;

关键词：

Nanomaterials; Nanoparticles; Carbon nanotubes; Safety research; Suspension; Dispersion; Sonication; TITANIUM-DIOXIDE NANOPARTICLES; METAL-OXIDE NANOPARTICLES; WALLED-CARBON-NANOTUBES; INTRATRACHEAL INSTILLATION; PULMONARY TOXICITY; IN-VITRO; RESEARCH STRATEGIES; BLACK PARTICLES; DIFFERENT SIZES; ULTRAFINE;

D O I：

10.2486/indhealth.2012-0218

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Nanomaterials tend to agglomerate in aqueous media, resulting in inaccurate safety assessment of the biological response to these substances. The present study searched for suitable dispersion methods for the preparation of nanomaterial suspensions. Titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles were dispersed in a biocompatible dispersion medium by direct probe-type sonicator and indirect cup-type sonicator. Size characterization was completed using dynamic light scattering and transmission electron microscopy. A series of dispersion time and output power, as well as two different particle concentrations were tested. Microscopic contamination of metal titanium that broke away from the tip of the probe into the suspension was found. Size of agglomerated nanoparticles decreased with increase in sonication time or output power. Particle concentration did not show obvious effect on size distribution of TiO2 nanoparticles, while significant reduction of secondary diameter of ZnO was observed at higher concentration. A practicable protocol was then adopted and sizes of well-dispersed nanoparticles increased by less than 10% at 7 d after sonication. Multi-walled carbon nanotubes were also well dispersed by the same protocol. The cup-type sonicator might be a useful alternative to the traditional bath-type sonicator or probe-type sonicator based on its effective energy delivery and assurance of suspension purity.

引用

页码：54 / 65

页数：12

共 41 条

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