Incomplete host immunity favors the evolution of virulence in an emergent pathogen

被引：48
作者：
Fleming-Davies, Arietta E. [1 ,2 ,3 ]
Williams, Paul D. [4 ]
Dhondt, Andre A. [5 ]
Dobson, Andrew P. [4 ,6 ]
Hochachka, Wesley M. [5 ]
Leon, Ariel E. [2 ]
Ley, David H. [7 ]
Osnas, Erik E. [8 ]
Hawley, Dana M. [2 ]
机构：
[1] Univ San Diego, Dept Biol, San Diego, CA 92110 USA
[2] Virginia Tech, Dept Biol Sci, Blacksburg, VA 24061 USA
[3] Radford Univ, Dept Biol, Radford, VA 24141 USA
[4] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA
[5] Cornell Univ, Lab Ornithol, Ithaca, NY 14850 USA
[6] Santa Fe Inst, Santa Fe, NM 87501 USA
[7] North Carolina State Univ, Dept Populat Hlth & Pathobiol, Coll Vet Med, Raleigh, NC 27607 USA
[8] US Fish & Wildlife Serv, Anchorage, AK 99503 USA
来源：
SCIENCE | 2018年 / 359卷 / 6379期
关键词：
MYCOPLASMA-GALLISEPTICUM INFECTION; IN-HOUSE FINCHES; RESISTANCE; REINFECTION; DYNAMICS; DISEASE; VIRUS; TRANSMISSION; VACCINATION; POPULATION;
D O I：
10.1126/science.aao2140
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Immune memory evolved to protect hosts from reinfection, but incomplete responses that allow future reinfection may inadvertently select for more-harmful pathogens. We present empirical and modeling evidence that incomplete immunity promotes the evolution of higher virulence in a natural host-pathogen system. We performed sequential infections of house finches with Mycoplasma gallisepticum strains of various levels of virulence. Virulent bacterial strains generated stronger host protection against reinfection than less virulent strains and thus excluded less virulent strains from infecting previously exposed hosts. In a two-strain model, the resulting fitness advantage selected for an almost twofold increase in pathogen virulence. Thus, the same immune systems that protect hosts from infection can concomitantly drive the evolution of more-harmful pathogens in nature.
引用
收藏
页码：1030 / +
页数：4
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