Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours

被引：13

作者：

Vozdova, Miluse ^{[1
]}

Kubickova, Svatava ^{[1
]}

Fictum, Petr ^{[2
]}

Frohlich, Jan ^{[1
]}

Jelinek, Frantisek ^{[3
]}

Rubes, Jiri ^{[1
]}

机构：

[1] Cent European Inst Technol, Vet Res Inst, Hudcova 70, Brno 62100, Czech Republic

[2] Univ Vet & Pharmaceut Sci Brno, Fac Vet Med, Dept Pathol Morphol & Parasitol, Palackeho Tr 1946-1, Brno 61242, Czech Republic

[3] Vet Histopathol Lab, Vet Pathol, Sojovicka 16, Prague 19700, Czech Republic

来源：

VETERINARY JOURNAL | 2019年 / 247卷

关键词：

c-kit; Dog; Mast cell tumour; Mutation; TP53; COMMON; DOGS; P53;

D O I：

10.1016/j.tvjl.2019.03.005

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Cutaneous mast cell tumours (MCI') are among the most frequent malignancies in dogs. Their clinical behaviour is highly variable and, with the exception of mutations in the c-kit gene, little is known about their genetic aetiology. The mutational status of the c-kit exons 8, 9 and 11, and exons 5-8 of the TP53 gene was analysed to find markers for molecular stratification of MCTs and predictors of clinical outcome. Mutations in the c-kit gene were detected in 19.5% (n = 8/41) samples and their presence was significantly associated with the high histopathologica I grade (P=0.038). Mutations in the DNA binding domain of the TP53 gene were found in 14.6% (n = 6/41) of the analysed MCTs, and their frequency was similar in low and high grade MCTs (P>0.05). TP53 mutations were not useful prognostic factors in this sample of canine cutaneous MCTs. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：71 / 74

页数：4

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