Prolonged Survival of Patients with Breast Cancer-related Leptomeningeal Metastases

被引：0

作者：

Le Rhun, Emilie ^{[1
,2
]}

Taillibert, Sophie ^{[3
,4
]}

Zairi, Fahed ^{[2
]}

Pannier, Diane ^{[1
]}

Boulanger, Thomas ^{[5
]}

Andre, Charles ^{[6
]}

Cazin, Jean Louis ^{[7
]}

Dubois, Francois ^{[2
]}

Bonneterre, Jacques ^{[8
]}

Chamberlain, Marc C. ^{[9
]}

机构：

[1] Ctr Oscar Lambret, Dept Med Oncol, Breast Unit, F-59020 Lille, France

[2] Univ Hosp, Dept Neurosurg, Lille, France

[3] Grp Hosp Pitie Salpetriere, Dept Radiat Oncol, F-75634 Paris, France

[4] Grp Hosp Pitie Salpetriere, Dept Neurooncol, F-75634 Paris, France

[5] Ctr Oscar Lambret, Dept Radiol, F-59020 Lille, France

[6] Ctr Oscar Lambret, Dept Pathol, F-59020 Lille, France

[7] Ctr Oscar Lambret, Dept Clin Pharm, F-59020 Lille, France

[8] Univ Lille Nord France, Lille, France

[9] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

来源：

ANTICANCER RESEARCH | 2013年 / 33卷 / 05期

关键词：

Leptomeningeal metastases; neoplastic meningitis; intra-CSF chemotherapy; liposomal cytarabine; breast cancer; multimodality treatment; CARCINOMATOUS MENINGITIS SECONDARY; PROGNOSTIC-FACTORS; MENINGEAL CARCINOMATOSIS; NEOPLASTIC MENINGITIS; INTRATHECAL METHOTREXATE; CLINICAL-FEATURES; CHEMOTHERAPY; TUMOR;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Prolonged overall survival (OS) has been reported for selected patients with leptomeningeal metastases (LM). The management and treatment of such patients is poorly-described. We report our experience on breast cancer (BC)-associated LM and patients with prolonged survival. Patients and Methods: Eleven patients with BC and LM had an OS >12 months in which treatment is described. Results: Combined intra-cerebro spinal fluid (CSF) and systemic treatment were administered until disease progression or toxicity in all but two patients. Involved-field radiotherapy was administered to two patients. Median OS in this selected cohort following LM diagnosis, was 21.0 (range=13-33.3) months. Conclusion: Prolonged OS but also prolonged responses can be observed in BC with LM. An individualized and multi-disciplinary approach is advised for the management of these patients.

引用

页码：2057 / 2063

页数：7

共 46 条

[1] Meningeal carcinomatosis in breast cancer: prognostic factors and outcome
Alexandre Silva de Azevedo, Carla Rameri
Sousa Cruz, Marcelo Rocha
Domingos Chinen, Ludmilla Thome
Peres, Stela Verzinhasse
Peterlevitz, Marcos Aurelio
de Azevedo Pereira, Artur Eugenio
Fanelli, Marcello Ferretti
Gimenes, Daniel Luiz
[J]. JOURNAL OF NEURO-ONCOLOGY, 2011, 104 (02) : 565 - 572
[2] Clinicopathologic characteristics and prognostic factors in 420 metastatic breast cancer patients with central nervous system metastasis
Altundag, Kadri
Bondy, Melissa L.
Mirza, Nadeern Q.
Kau, Shu-Wan
Broglio, Kristine
Hortobagyi, Gabriel N.
Rivera, Edgardo
[J]. CANCER, 2007, 110 (12) : 2640 - 2647
[3] [Anonymous], Clinical practice guidelines in oncology
[4] The relevance of intraventricular chemotherapy for leptomeningeal metastasis in breast cancer: a randomised study
Boogerd, W
van den Bent, MJ
Koehler, PJ
Heimans, JJ
van der Sande, JJ
Aaronson, NK
Hart, AAM
Benraadt, J
Vecht, CJ
[J]. EUROPEAN JOURNAL OF CANCER, 2004, 40 (18) : 2726 - 2733
[5] BOOGERD W, 1991, CANCER, V67, P1685, DOI 10.1002/1097-0142(19910315)67:6<1685::AID-CNCR2820670635>3.0.CO
[6] 2-M
[7] ACUTE FEVER AND DELAYED LEUKOENCEPHALOPATHY FOLLOWING LOW-DOSE INTRAVENTRICULAR METHOTREXATE
BOOGERD, W
VANDERSANDE, JJ
MOFFIE, D
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1988, 51 (10) : 1277 - 1283
[8] Brem Steven S, 2005, J Natl Compr Canc Netw, V3, P644
[9] Neoplastic meningitis
Chamberlain, Marc C.
[J]. NEUROLOGIST, 2006, 12 (04) : 179 - 187
[10] Leptomeningeal metastasis
Chamberlain, Marc C.
[J]. CURRENT OPINION IN NEUROLOGY, 2009, 22 (06) : 665 - 674

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