Reasons for poor adherence to antiretroviral therapy postnatally in HIV-1 infected women treated for their own health: experiences from the Mitra Plus study in Tanzania

被引:85
作者
Ngarina, Matilda [1 ,5 ,6 ]
Popenoe, Rebecca [2 ,3 ]
Kilewo, Charles [4 ]
Biberfeld, Gunnel [5 ,6 ]
Ekstrom, Anna Mia [2 ,3 ]
机构
[1] Muhimbili Natl Hosp, Dept Obstet & Gynaecol, Dar Es Salaam, Tanzania
[2] Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden
[3] Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden
[4] Muhimbili Univ Hlth & Allied Sci, Dept Obstet & Gynaecol, Dar Es Salaam, Tanzania
[5] Karolinska Inst, Swedish Inst Communicable Dis Control SMI, Stockholm, Sweden
[6] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden
关键词
Prevention of mother-to-child transmission; Postnatal; Antiretroviral drugs; Adherence; Tanzania; TO-CHILD TRANSMISSION; SUB-SAHARAN AFRICA; DAR-ES-SALAAM; DRUG-RESISTANCE; HIV; PREVENTION; BARRIERS; PREGNANCY; MOTHERS;
D O I
10.1186/1471-2458-13-450
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: In a study of prevention of mother-to-child transmission of HIV (PMTCT) by triple antiretroviral therapy (ART) in Dar es Salaam, Tanzania (the Mitra Plus study), retrospective viral load testing revealed a high and increasing frequency of detectable viral load during follow-up for two years postnatally in women given continuous ART for their own health suggesting poor adherence. This study explored women's own perceived barriers to adherence to ART post-delivery so as to identify ways to facilitate better drug adherence among women in need of ART for their own health. Methods: Semi-structured interviews were conducted with 23 of the 48 women who had detectable viral load at 24 months postnatally. Content analysis was used to analyze the data. Results: Most women in the study did not acknowledge poor adherence until confronted with the viral load figures. Then, however, they revealed multiple reasons for failing to adhere. They said that their motivation to take ART decreased once they had protected their children from becoming infected and successfully weaned them. Feeling well for some, and a feeling of hopelessness for others, also decreased motivation to continue ART. The overwhelming demands of everyday life, poverty and lack of empowerment also posed significant barriers to long-term adherence. The need to keep their HIV status a secret and not let anyone see them taking the drugs was another steep barrier. Conclusion: Reasons for postnatal failure to adhere by mothers put on ART for life during pregnancy included lack of motivation to continue ART after weaning the child, poverty and stigma. Projects that simultaneously address stigma, poverty and women's lack of empowerment may be necessary for PMTCT and ART to reach their full potential. Our results indicate that the new WHO proposal to start all HIV-infected pregnant women on lifelong ART regardless of CD4 cell count needs to address the challenging realities of women in resource-poor contexts if it is to be successful.
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