It is our purpose in this paper first to introduce the class of total asymptotically nonexpansive nonself mappings and to prove the demiclosed principle for such mappings in spaces. Then, a new mixed Agarwal-O'Regan-Sahu type iterative scheme for approximating a common fixed point of two total asymptotically nonexpansive mappings and two total asymptotically nonexpansive nonself mappings is constructed. Under suitable conditions, some strong convergence theorems and Delta-convergence theorems are proved in a space. Our results improve and extend the corresponding results of Agarwal, O'Regan and Sahu (J. Nonlinear Convex Anal. 8(1):61-79, 2007), Guo et al. (Fixed Point Theory Appl. 2012:224, 2012. doi:10.1186/1687-1812-2012-224), Sahin et al. (Fixed Point Theory Appl. 2013:12, 2013. doi:10.1186/1687-1812-2013-12), Chang et al. (Appl. Math. Comput. 219:2611-2617, 2012), Khan and Abbas (Comput. Math. Appl. 61:109-116, 2011), Khan et al. (Nonlinear Anal. 74:783-791, 2011), Xu (Nonlinear Anal., Theory Methods Appl. 16(12):1139-1146, 1991), Chidume et al. (J. Math. Anal. Appl. 280:364-374, 2003) and others.