Immune cell engineering: opportunities in lung cancer therapeutics

被引：6

作者：

Bhargava, Arpit ^{[1
]}

Mishra, Dinesh Kumar ^{[2
]}

Tiwari, Rajnarayan ^{[1
]}

Lohiya, Nirmal Kumar ^{[3
]}

Goryacheva, Irina Yu ^{[4
]}

Mishra, Pradyumna Kumar ^{[1
]}

机构：

[1] Kamla Nehru Hosp, ICMR Natl Inst Res Environm Hlth, Dept Mol Biol, Bldg Gandhi Med Coll Campus, Bhopal 462001, Madhya Pradesh, India

[2] Indore Inst Pharm, Indore, India

[3] Univ Rajasthan, Sch Life Sci, Jaipur, Rajasthan, India

[4] Saratov NG Chernyshevskii State Univ, Dept Gen & Inorgan Chem, Saratov, Russia

来源：

DRUG DELIVERY AND TRANSLATIONAL RESEARCH | 2020年 / 10卷 / 05期

关键词：

Nanoengineering; Cancer therapeutics; CAR-T-cells; Dendritic cells; NK-cells; SOLID LIPID NANOPARTICLES; ANTIGEN-PRESENTING CELLS; KILLER T-CELLS; GASTROINTESTINAL TUMOR-IMMUNOTHERAPY; IRON-OXIDE NANOPARTICLES; HUMAN DENDRITIC CELLS; PHASE-III TRIAL; NATURAL-KILLER; IN-VITRO; GOLD NANOPARTICLES;

D O I：

10.1007/s13346-020-00719-2

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Engineered immune cells offer a prime therapeutic alternate for some aggressive and frequently occurring malignancies like lung cancer. These therapies were reported to result in tumor regression and overall improvement in patient survival. However, studies also suggest that the presence of cancer cell-induced immune-suppressive microenvironment, off-target toxicity, and difficulty in concurrent imaging are some prime impendent in the success of these approaches. The present article reviews the need and significance of the currently available immune cell-based strategies for lung cancer therapeutics. It also showcases the utility of incorporating nanoengineered strategies and details the available formulations of nanocarriers. In last, it briefly discussed the existing methods for nanoparticle fuctionalization and challenges in translating basic research to the clinics. Graphical

引用

页码：1203 / 1227

页数：25

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