Middle-aged healthy women and Alzheimer's disease patients present an overlapping of brain cell transcriptional profile

被引：27
作者：
Sanfilippo, Cristina [1 ]
Castrogiovanni, Paola [2 ]
Imbesi, Rosa [2 ]
Tibullo, Daniele [3 ]
Li Volti, Giovanni [3 ]
Barbagallo, Ignazio [4 ]
Vicario, Nunzio [5 ]
Musumeci, Giuseppe [2 ]
Di Rosa, Michelino [2 ]
机构：
[1] IRCCS Ctr Neurolesi Bonino Pulejo, Str Statale 113,C Da Casazza, I-98124 Messina, Italy
[2] Univ Catania, Sch Med, Dept Biomed & Biotechnol Sci, Human Anat & Histol Sect, Catania, Italy
[3] Univ Catania, Dept Biomed & Biotechnol Sci, Sect Med Biochem, Via S Sofia 89, I-95123 Catania, Italy
[4] Univ Catania, Sect Biochem, Dept Drug Sci, Catania, Italy
[5] Univ Catania, Dept Biomed & Biotechnol Sci, Sect Physiol, Via S Sofia 89, I-95123 Catania, Italy
来源：
NEUROSCIENCE | 2019年 / 406卷
关键词：
Aging; Alzheimer's disease; PFC; Microglia; Microarray; SEX-DIFFERENCES; GENDER-DIFFERENCES; SYSTEMS-APPROACH; GENE-EXPRESSION; MICROGLIA; IMPACT; NETWORKS; REGIONS; CORTEX;
D O I：
10.1016/j.neuroscience.2019.03.008
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Exploring sexual dimorphisms in the brain morphology is important for their impact and therapeutic implications for several neurological diseases. The hypothesis that sex could influence the transcriptome of brain cells could be the basis regarding the different response to cognitive decline identified inmen and women. In this paper, we analyzed several prefrontal cortices (PFC) microarrays datasets of young/middle-aged healthy subjects and then Alzheimer's disease (AD) patients, according to the sex. The significant transcriptomes were overlapped with the main genes characterizing cells of the central nervous system (CNS) in order to determine the respective weighted percentages of significantly expression gene modulation (WPSEG). We identified differences in brain transcriptional activity between young and middle-aged. In middle-aged women, the WPSEG were higher for the Astrocytes, the Endotheliocytes, and the Microglia. In addition, the sex-matched analysis of transcriptome identified a convergentmolecular signature inmen and women AD patients. Furthermore, the WPSEG belonging to CNS cells in PFC of healthy middle-aged subjects was correlated to AD profiles according to the sex. Since our results, it is possible to conclude that during the aging the PFC' cells adopt transcriptional strategies sex-dependent that could potentially control the development of neurodegenerative diseases. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：333 / 344
页数：12
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