IFITM1 promotes the metastasis of human colorectal cancer via CAV-1

被引：73

作者：

Yu, Fang ^{[1
]}

Xie, Dan ^{[2
]}

Ng, Samuel S. ^{[3
]}

Lum, Ching Tung ^{[3
]}

Cai, Mu-Yan ^{[4
]}

Cheung, William K. ^{[3
]}

Kung, Hsiang-Fu ^{[5
,6
]}

Lin, Guimiao ^{[7
]}

Wang, Xiaomei ^{[7
]}

Lin, Marie C. ^{[7
]}

机构：

[1] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Pathol, Hangzhou 310027, Peoples R China

[2] Sun Yat Sen Univ, Ctr Canc, Dept Expt Res, Guangzhou, Guangdong, Peoples R China

[3] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[4] Sun Yat Sen Univ, Ctr Canc, Dept Pathol, Guangzhou, Guangdong, Peoples R China

[5] Kunming Med Univ, HK Acad Workstat, Kunming, Peoples R China

[6] Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China

[7] Shenzhen Univ, Sch Med, Shenzhen Key Lab Translat Med Tumor, Shenzhen, Peoples R China

来源：

CANCER LETTERS | 2015年 / 368卷 / 01期

关键词：

IFITM1; Colorectal cancer; Metastasis; CAV1; INDUCED TRANSMEMBRANE PROTEIN-1; EXPRESSION SUPPRESSES GROWTH; SQUAMOUS-CELL CARCINOMA; GASTRIC-CANCER; BETA-CATENIN; CAVEOLIN-1; TUMORIGENESIS; FAMILY; ACTIVATION; PROLIFERATION;

D O I：

10.1016/j.canlet.2015.07.034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interferon-induced transmembrane protein 1 (IFITM1) is one of the interferon-induced transmembrane protein family members. In this study, we reported that the elevated IFITM1 expression in human colorectal cancer (CRC) significantly correlated with CRC lymph node and distance metastasis as well as a more advanced clinical stage. Importantly, elevated IFITM1 expression is an independent prognostic factor for poor survival. To investigate the molecular mechanisms, we showed that over-expression of IFITM1 in CRC cells promoted, whereas knockdown of IFITM1 expression inhibited, cell migration/invasion and tumorigenicity in Vitro. Furthermore, we identified Caveolin-1 (CAV1) as a downstream target of IFITM1-induced cell invasion, as knockdown of CAV1 abrogated siIFITM1 mediated inhibition of cell invasion in CRC cells. In addition, in a CRC cohort of 229 patients, the expression of IFITM1 inversely correlated with the expression of CAV1. These results suggested that IFITM1 promotes the aggressiveness of CRC cells, and it is a potential prognostic marker and therapeutic target for CRC. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：135 / 143

页数：9

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