Cancer-associated fibroblasts regulate the biological behavior of cancer cells and stroma in gastric cancer (Review)

被引：33
作者：
Zhang, Qian [1 ]
Peng, Chunwei [2 ,3 ]
机构：
[1] Wuhan Univ, Dept Clin Coll 2, Wuhan 430071, Hubei, Peoples R China
[2] Wuhan Univ, Dept Oncol, Zhongnan Hosp, Hubei Key Lab Tumor Biol Behav, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China
[3] Hubei Canc Clin Study Ctr, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China
来源：
ONCOLOGY LETTERS | 2018年 / 15卷 / 01期
基金：
中国国家自然科学基金;
关键词：
cancer-associated fibroblast; vascular endothelial growth factor; gastric cancer; angiogenesis; tumor microenvironment; TUMOR-ASSOCIATED MACROPHAGES; ENDOTHELIAL GROWTH-FACTOR; COLORECTAL-CANCER; BREAST-CANCER; TGF-BETA; MATRIX METALLOPROTEINASES; EXTRACELLULAR-MATRIX; INFLAMMATORY FACTORS; ANGIOGENIC FACTORS; UP-REGULATION;
D O I：
10.3892/ol.2017.7385
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gastric cancer (GC) is a frequently diagnosed type of cancer in China, and is associated with a high mortality rate. The biological behavior of GC requires investigation in order to provide an evidence base for the development of strategies to prevent and treat GC. For this purpose, the present review outlines the process of tumor microenvironment (TME) evolution, including the dynamic biological behavior of different types of cancer cell and stroma. Cancer-associated fibroblasts (CAFs) serve as prominent stromal cellular components in the GC TME, and exhibit an essential function in GC progression. In the present study, the function of CAFs in cancer cell proliferation, cell migration, invasion, extracellular matrix remodeling, pathological angiogenesis and immune cell infiltration were investigated. The studies discussed in the present review demonstrate that the cross-talk between CAF, cancer cells and tumor stroma promotes GC progression.
引用
收藏
页码：691 / 698
页数：8
相关论文
共 105 条
  • [1] The prognostic significance of tumor-associated stroma in invasive breast carcinoma
    Ahn, Soomin
    Cho, Junhun
    Sung, Jiyoun
    Lee, Jeong Eon
    Nam, Seok Jin
    Kim, Kyoung-Mee
    Cho, Eun Yoon
    [J]. TUMOR BIOLOGY, 2012, 33 (05) : 1573 - 1580
  • [2] HSD3B and Gene-Gene Interactions in a Pathway-Based Analysis of Genetic Susceptibility to Bladder Cancer
    Andrew, Angeline S.
    Hu, Ting
    Gu, Jian
    Gui, Jiang
    Ye, Yuanqing
    Marsit, Carmen J.
    Kelsey, Karl T.
    Schned, Alan R.
    Tanyos, Sam A.
    Pendleton, Eben M.
    Mason, Rebecca A.
    Morlock, Elaine V.
    Zens, Michael S.
    Li, Zhongze
    Moore, Jason H.
    Wu, Xifeng
    Karagas, Margaret R.
    [J]. PLOS ONE, 2012, 7 (12):
  • [3] CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth
    Augsten, Martin
    Hagglof, Christina
    Olsson, Eleonor
    Stolz, Claudia
    Tsagozis, Panagiotis
    Levchenko, Tetyana
    Frederick, Mitchell J.
    Borg, Ake
    Micke, Patrick
    Egevad, Lars
    Ostman, Arne
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (09) : 3414 - 3419
  • [4] FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7
    Bai, Yu-Pan
    Shang, Kun
    Chen, Huan
    Ding, Fei
    Wang, Zhen
    Liang, Chen
    Xu, Ye
    Sun, Meng-Hong
    Li, Ying-yi
    [J]. CANCER SCIENCE, 2015, 106 (10) : 1278 - 1287
  • [5] THE FGF FAMILY OF GROWTH-FACTORS AND ONCOGENES
    BASILICO, C
    MOSCATELLI, D
    [J]. ADVANCES IN CANCER RESEARCH, 1992, 59 : 115 - 165
  • [6] Tumour-derived prostaglandin E2 and transforming growth factor-β synergize to inhibit plasmacytoid dendritic cell-derived interferon-α
    Bekeredjian-Ding, Isabelle
    Schafer, Meike
    Hartmann, Evelyn
    Pries, Ralph
    Parcina, Marijo
    Schneider, Philip
    Giese, Thomas
    Endres, Stefan
    Wollenberg, Barbara
    Hartmann, Gunther
    [J]. IMMUNOLOGY, 2009, 128 (03) : 439 - 450
  • [7] Hepatic Carcinoma-Associated Fibroblasts Promote an Adaptative Response in Colorectal Cancer Cells That Inhibit Proliferation and Apoptosis: Nonresistant Cells Die by Nonapoptotic Cell Death
    Berdiel-Acer, Mireia
    Bohem, Monika E.
    Lopez-Doriga, Adriana
    Vidal, August
    Salazar, Ramon
    Martinez-Iniesta, Maria
    Santos, Cristina
    Sanjuan, Xavier
    Villanueva, Alberto
    Mollevi, David G.
    [J]. NEOPLASIA, 2011, 13 (10): : 931 - 946
  • [8] Hypertension and Circulating Cytokines and Angiogenic Factors in Patients With Advanced Non-Clear Cell Renal Cell Carcinoma Treated With Sunitinib: Results From a Phase II Trial
    Bilen, Mehmet Asim
    Zurita, Amado J.
    Ilias-Khan, Nasreen A.
    Chen, Hsiang-Chun
    Wang, Xuemei
    Kearney, Alper Y.
    Hodges, Sherie
    Jonasch, Eric
    Huang, Shixia
    Khakoo, Aarif Yusuf
    Tannir, Nizar M.
    [J]. ONCOLOGIST, 2015, 20 (10) : 1140 - 1148
  • [9] Remodelling the extracellular matrix in development and disease
    Bonnans, Caroline
    Chou, Jonathan
    Werb, Zena
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (12) : 786 - 801
  • [10] Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene
    Borrello, MG
    Alberti, L
    Fischer, A
    Degl'Innocenti, D
    Ferrario, C
    Gariboldi, M
    Marchesi, F
    Allavena, P
    Greco, A
    Collini, P
    Pilotti, S
    Cassinelli, G
    Bressan, P
    Fugazzola, L
    Mantovani, A
    Pierotti, MA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (41) : 14825 - 14830
12345678910