Modeling psychiatric disorders at the cellular and network levels

被引：87

作者：

Brennand, K. J. ^{[1
]}

Simone, A. ^{[1
]}

Tran, N. ^{[1
]}

Gage, F. H. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

来源：

MOLECULAR PSYCHIATRY | 2012年 / 17卷 / 12期

关键词：

autism spectrum disorders; bipolar disorder; neurons; schizophrenia; stem cells; PLURIPOTENT STEM-CELLS; CORTICAL PYRAMIDAL NEURONS; DENDRITIC SPINE DENSITY; CPG-BINDING PROTEIN-2; MOSSY FIBER SYNAPSES; GENETIC MOUSE MODEL; FRAGILE-X-SYNDROME; PREFRONTAL CORTEX; RETT-SYNDROME; SYNAPTIC PLASTICITY;

D O I：

10.1038/mp.2012.20

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although psychiatric disorders such as autism spectrum disorders, schizophrenia and bipolar disorder affect a number of brain regions and produce a complex array of clinical symptoms, basic phenotypes likely exist at the level of single neurons and simple networks. Being highly heritable, it is hypothesized that these disorders are amenable to cell-based studies in vitro. Using induced pluripotent stem cell-derived neurons and/or induced neurons from fibroblasts, limitless numbers of live human neurons can now be generated from patients with a genetic background permissive to the disease state. We predict that cell-based studies will ultimately contribute to our understanding of the initiation, progression and treatment of these psychiatric disorders. Molecular Psychiatry (2012) 17, 1239-1253; doi:10.1038/mp.2012.20; published online 3 April 2012

引用

页码：1239 / 1253

页数：15

共 140 条

[71] A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition [J].

Kvajo, Mirna ;

McKellar, Heather ;

Arguello, P. Alexander ;

Drew, Liam J. ;

Moore, Holly ;

MacDermott, Amy B. ;

Karayiorgou, Maria ;

Gogos, Joseph A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (19) :7076-7081

[72] The neuregulin-1 receptor ErbB4 controls Glutamatergic synapse maturation and plasticity [J].

Li, Bo ;

Woo, Ran-Sook ;

Mei, Lin ;

Malinow, Roberto .

NEURON, 2007, 54 (04) :583-597

[73] Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice [J].

Li, Weidong ;

Zhou, Yu ;

Jentsch, J. David ;

Brown, Robert A. M. ;

Tian, Xiaoli ;

Ehninger, Dan ;

Hennah, William ;

Peltonen, Leena ;

Lonnqvist, Jouko ;

Huttunen, Matti O. ;

Kaprio, Jaakko ;

Trachtenberg, Joshua T. ;

Silva, Alcino J. ;

Cannon, Tyrone D. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (46) :18280-18285

[74] Specification of motoneurons from human embryonic stem cells [J].

Li, XJ ;

Du, ZW ;

Zarnowska, ED ;

Pankratz, M ;

Hansen, LO ;

Pearce, RA ;

Zhang, SC .

NATURE BIOTECHNOLOGY, 2005, 23 (02) :215-221

[75] RNA-Seq of Human Neurons Derived from iPS Cells Reveals Candidate Long Non-Coding RNAs Involved in Neurogenesis and Neuropsychiatric Disorders [J].

Lin, Mingyan ;

Pedrosa, Erika ;

Shah, Abhishek ;

Hrabovsky, Anastasia ;

Maqbool, Shahina ;

Zheng, Deyou ;

Lachman, Herbert M. .

PLOS ONE, 2011, 6 (09)

[76] Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells [J].

Lister, Ryan ;

Pelizzola, Mattia ;

Kida, Yasuyuki S. ;

Hawkins, R. David ;

Nery, Joseph R. ;

Hon, Gary ;

Antosiewicz-Bourget, Jessica ;

O'Malley, Ronan ;

Castanon, Rosa ;

Klugman, Sarit ;

Downes, Michael ;

Yu, Ruth ;

Stewart, Ron ;

Ren, Bing ;

Thomson, James A. ;

Evans, Ronald M. ;

Ecker, Joseph R. .

NATURE, 2011, 471 (7336) :68-U84

[77] Tangential neuronal migration controls axon guidance:: A role for neuregulin-1 in thalamocortical axon navigation [J].

López-Bendito, G ;

Cautinat, A ;

Sánchez, JA ;

Bielle, F ;

Flames, N ;

Garratt, AN ;

Talmage, DA ;

Role, LW ;

Charnay, P ;

Marín, O ;

Garel, S .

CELL, 2006, 125 (01) :127-142

[78] Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling [J].

Mao, Yingwei ;

Ge, Xuecai ;

Frank, Christopher L. ;

Madison, Jon M. ;

Koehler, Angela N. ;

Doud, Mary Kathryn ;

Tassa, Carlos ;

Berry, Erin M. ;

Soda, Takahiro ;

Singh, Karun K. ;

Biechele, Travis ;

Petryshen, Tracey L. ;

Moon, Randall T. ;

Haggarty, Stephen J. ;

Tsai, Li-Huei .

CELL, 2009, 136 (06) :1017-1031

[79] A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells [J].

Marchetto, Maria C. N. ;

Carromeu, Cassiano ;

Acab, Allan ;

Yu, Diana ;

Yeo, Gene W. ;

Mu, Yangling ;

Chen, Gong ;

Gage, Fred H. ;

Muotri, Alysson R. .

CELL, 2010, 143 (04) :527-539

[80] Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells [J].

Marchetto, Maria C. N. ;

Muotri, Alysson R. ;

Mu, Yangling ;

Smith, Alan M. ;

Cezar, Galbriela G. ;

Gage, Fred H. .

CELL STEM CELL, 2008, 3 (06) :649-657

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