Modeling psychiatric disorders at the cellular and network levels

被引：87
作者：
Brennand, K. J. [1 ]
Simone, A. [1 ]
Tran, N. [1 ]
Gage, F. H. [1 ]
机构：
[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA
来源：
MOLECULAR PSYCHIATRY | 2012年 / 17卷 / 12期
关键词：
autism spectrum disorders; bipolar disorder; neurons; schizophrenia; stem cells; PLURIPOTENT STEM-CELLS; CORTICAL PYRAMIDAL NEURONS; DENDRITIC SPINE DENSITY; CPG-BINDING PROTEIN-2; MOSSY FIBER SYNAPSES; GENETIC MOUSE MODEL; FRAGILE-X-SYNDROME; PREFRONTAL CORTEX; RETT-SYNDROME; SYNAPTIC PLASTICITY;
D O I：
10.1038/mp.2012.20
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although psychiatric disorders such as autism spectrum disorders, schizophrenia and bipolar disorder affect a number of brain regions and produce a complex array of clinical symptoms, basic phenotypes likely exist at the level of single neurons and simple networks. Being highly heritable, it is hypothesized that these disorders are amenable to cell-based studies in vitro. Using induced pluripotent stem cell-derived neurons and/or induced neurons from fibroblasts, limitless numbers of live human neurons can now be generated from patients with a genetic background permissive to the disease state. We predict that cell-based studies will ultimately contribute to our understanding of the initiation, progression and treatment of these psychiatric disorders. Molecular Psychiatry (2012) 17, 1239-1253; doi:10.1038/mp.2012.20; published online 3 April 2012
引用
收藏
页码：1239 / 1253
页数：15
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