Inflammasomes and viruses: cellular defence versus viral offence

被引：58

作者：

Gram, Anna M. ^{[1
]}

Frenkel, Joost ^{[2
]}

Ressing, Maaike E. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Paediat Div, Dept Gen Paediat, Utrecht, Netherlands

来源：

JOURNAL OF GENERAL VIROLOGY | 2012年 / 93卷

关键词：

INTERLEUKIN-1-BETA CONVERTING-ENZYME; SARCOMA-ASSOCIATED HERPESVIRUS; INNATE IMMUNE SENSOR; TOLL-LIKE RECEPTORS; INFLUENZA-VIRUS; VACCINIA VIRUS; AUTOINFLAMMATORY DISEASE; INFLAMMATORY CASPASES; NLRP3; INFLAMMASOME; CUTTING EDGE;

D O I：

10.1099/vir.0.042978-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pro-inflammatory cytokines are important mediators in immune responses against invading pathogens, including viruses. Precursors of the pro-inflammatory cytokines interleukin (IL)-1 beta and IL-18 are processed by caspase-1. Caspase-1 is activated through autocleavage, but how this is regulated remained elusive for a long time. In 2002, an intracellular multimeric complex was discovered that facilitated caspase-1 cleavage and was termed 'inflammasome'. To date, different inflammasomes have been described, which recognize a variety of ligands and pathogens. In this review, we discuss the role of inflammasomes in sensing viral infection as well as the evasion strategies that viruses developed to circumvent inflammasome-dependent effects.

引用

页码：2063 / 2075

页数：13

共 95 条

[1] An Autoinflammatory Disease with Deficiency of the Interleukin-1-Receptor Antagonist [J].

Aksentijevich, Ivona ;

Masters, Seth L. ;

Ferguson, Polly J. ;

Dancey, Paul ;

Frenkel, Joost ;

van Royen-Kerkhoff, Annet ;

Laxer, Ron ;

Tedgard, Ulf ;

Cowen, Edward W. ;

Pham, Tuyet-Hang ;

Booty, Matthew ;

Estes, Jacob D. ;

Sandler, Netanya G. ;

Plass, Nicole ;

Stone, Deborah L. ;

Turner, Maria L. ;

Hill, Suvimol ;

Butman, John A. ;

Schneider, Rayfel ;

Babyn, Paul ;

El-Shanti, Hatem I. ;

Pope, Elena ;

Barron, Karyl ;

Bing, Xinyu ;

Laurence, Arian ;

Lee, Chyi-Chia R. ;

Chapelle, Dawn ;

Clarke, Gillian I. ;

Ohson, Kamal ;

Nicholson, Marc ;

Gadina, Massimo ;

Yang, Barbara ;

Korman, Benjamin D. ;

Gregersen, Peter K. ;

van Hagen, P. Martin ;

Hak, A. Elisabeth ;

Huizing, Marjan ;

Rahman, Proton ;

Douek, Daniel C. ;

Remmers, Elaine F. ;

Kastner, Daniel L. ;

Goldbach-Mansky, Raphaela .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (23) :2426-2437

[2] A SOLUBLE RECEPTOR FOR INTERLEUKIN-1-BETA ENCODED BY VACCINIA VIRUS - A NOVEL MECHANISM OF VIRUS MODULATION OF THE HOST RESPONSE TO INFECTION [J].

ALCAMI, A ;

SMITH, GL .

CELL, 1992, 71 (01) :153-167

[3] The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA [J].

Allen, Irving C. ;

Scull, Margaret A. ;

Moore, Chris B. ;

Holl, Eda K. ;

McElvania-TeKippe, Erin ;

Taxman, Debra J. ;

Guthrie, Elizabeth H. ;

Pickles, Raymond J. ;

Ting, Jenny P. -Y. .

IMMUNITY, 2009, 30 (04) :556-565

[4] Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines [J].

Barker, Brianne R. ;

Taxman, Debra J. ;

Ting, Jenny P-Y .

CURRENT OPINION IN IMMUNOLOGY, 2011, 23 (05) :591-597

[5] Lysosomal localization and mechanism of membrane penetration influence nonenveloped virus activation of the NLRP3 inflammasome [J].

Barlan, A. U. ;

Danthi, P. ;

Wiethoff, C. M. .

VIROLOGY, 2011, 412 (02) :306-314

[6] Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome [J].

Barlan, A. U. ;

Griffin, T. M. ;

Mcguire, K. A. ;

Wiethoff, C. M. .

JOURNAL OF VIROLOGY, 2011, 85 (01) :146-155

[7] Inflammasomes: current understanding and open questions [J].

Bauernfeind, Franz ;

Ablasser, Andrea ;

Bartok, Eva ;

Kim, Sarah ;

Schmid-Burgk, Jonathan ;

Cavlar, Taner ;

Hornung, Veit .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2011, 68 (05) :765-783

[8] Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression [J].

Bauernfeind, Franz G. ;

Horvath, Gabor ;

Stutz, Andrea ;

Alnemri, Emad S. ;

MacDonald, Kelly ;

Speert, David ;

Fernandes-Alnemri, Teresa ;

Wu, Jianghong ;

Monks, Brian G. ;

Fitzgerald, Katherine A. ;

Hornung, Veit ;

Latz, Eicke .

JOURNAL OF IMMUNOLOGY, 2009, 183 (02) :787-791

[9] Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin [J].

Boyden, ED ;

Dietrich, WF .

NATURE GENETICS, 2006, 38 (02) :240-244

[10] An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome [J].

Buerckstuemmer, Tilmann ;

Baumann, Christoph ;

Blueml, Stephan ;

Dixit, Evelyn ;

Duernberger, Gerhard ;

Jahn, Hannah ;

Planyavsky, Melanie ;

Bilban, Martin ;

Colinge, Jacques ;

Bennett, Keiryn L. ;

Superti-Furga, Giulio .

NATURE IMMUNOLOGY, 2009, 10 (03) :266-272

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