Safety and Immunogenicity of a Single Low Dose or High Dose of Clade 2 Influenza A(H5N1) Inactivated Vaccine in Adults Previously Primed With Clade 1 Influenza A(H5N1) Vaccine

被引：11
作者：
Winokur, Patricia L. [1 ,2 ]
Patel, Shital M. [3 ,4 ]
Brady, Rebecca [5 ]
Chen, Wilbur H. [6 ]
El-Kamary, Samer S. [6 ]
Edwards, Kathryn [8 ]
Creech, C. Buddy [8 ]
Frey, Sharon
Keitel, Wendy A. [4 ]
Belshe, Robert [9 ]
Walter, Emmanuel [10 ]
Bellamy, Abbie [7 ]
Hill, Heather [7 ]
机构：
[1] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA
[2] Iowa City VA Healthcare Syst, Iowa City, IA USA
[3] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
[4] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA
[5] Cincinnati Childrens Hosp, Gamble Program Clin Studies, Cincinnati, OH USA
[6] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA
[7] EMMES Corp, Rockville, MD USA
[8] Vanderbilt Univ, Dept Pediat, Nashville, TN 37235 USA
[9] St Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
[10] Duke Univ, Sch Med, Dept Pediat, Durham, NC USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2015年 / 212卷 / 04期
基金：
美国国家卫生研究院;
关键词：
H5N1; influenza; vaccine; prime-boost; MEMORY B-CELLS; PANDEMIC INFLUENZA; ANTIGENIC VARIANT; HUMANS;
D O I：
10.1093/infdis/jiv087
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Influenza A(H5N1) vaccination strategies that improve the speed of the immunological response and cross-clade protection are desired. We compared the immunogenicity of a single 15-mu g or 90-mu g dose of A/H5N1/Indonesia/05/05 (clade 2) vaccine in adults who were previously primed with A/H5N1/Vietnam/1203/2004 (clade 1) vaccine. High-dose vaccine resulted in significantly higher titers to both clade 1 and 2 antigens. Clade 2 titers were unaffected by the previous dose of clade 1 vaccine. Low-dose priming with a mismatched pandemic influenza A(H5N1) vaccine would improve the rapidity, magnitude, and cross-reactivity of the immunological response following a single high-dose, unadjuvanted, pandemic vaccine.
引用
收藏
页码：525 / 530
页数：6
相关论文
共 50 条
  • [41] Cell mediated immune responses following revaccination with an influenza A/H5N1 vaccine
    Mbawuike, Innocent N.
    Atmar, Robert L.
    Patel, Shital M.
    Corry, David B.
    Winokur, Patricia L.
    Brady, Rebecca C.
    Chen, Wilbur H.
    Edwards, Kathryn M.
    Creech, C. Buddy
    Walter, Emmanuel B., Jr.
    Frey, Sharon E.
    Belshe, Robert B.
    Goll, Johannes B.
    Hill, Heather
    Keitel, Wendy A.
    VACCINE, 2016, 34 (04) : 547 - 554
  • [42] Protection level of AI H5N1 vaccine clade 2.1.3 commercial against AI H5N1 clade 2.3.2 virus from Ducks to SPF chicken in laboratory conditions
    Indriani, R.
    Dharmayanti, N. L. P., I
    JURNAL ILMU TERNAK DAN VETERINER, 2015, 20 (01) : 64 - 70
  • [43] A single dose of DNA vaccine based on conserved H5N1 subtype proteins provides protection against lethal H5N1 challenge in mice pre-exposed to H1N1 influenza virus
    Haiyan Chang
    Chaoyang Huang
    Jian Wu
    Fang Fang
    Wenjie Zhang
    Fuyan Wang
    Ze Chen
    Virology Journal, 7
  • [44] Preservation of the Immunogenicity of Dry-powder Influenza H5N1 Whole Inactivated Virus Vaccine at Elevated Storage Temperatures
    Felix Geeraedts
    Vinay Saluja
    Wouter ter Veer
    Jean-Pierre Amorij
    Henderik W. Frijlink
    Jan Wilschut
    Wouter L. J. Hinrichs
    Anke Huckriede
    The AAPS Journal, 2010, 12 : 215 - 222
  • [45] Preservation of the Immunogenicity of Dry-powder Influenza H5N1 Whole Inactivated Virus Vaccine at Elevated Storage Temperatures
    Geeraedts, Felix
    Saluja, Vinay
    ter Veer, Wouter
    Amorij, Jean-Pierre
    Frijlink, Henderik W.
    Wilschut, Jan
    Hinrichs, Wouter L. J.
    Huckriede, Anke
    AAPS JOURNAL, 2010, 12 (02): : 215 - 222
  • [46] H5N1 avian influenza in China
    Chen HuaLan
    SCIENCE IN CHINA SERIES C-LIFE SCIENCES, 2009, 52 (05): : 419 - 427
  • [47] Single dose of oil-adjuvanted inactivated vaccine protects chickens from lethal infections of highly pathogenic H5N1 influenza virus
    Do Hwang, Seon
    Kim, Hyun Soo
    Cho, Sung Whan
    Seo, Sang Heui
    VACCINE, 2011, 29 (11) : 2178 - 2186
  • [48] Safety and immunogenicity of an influenza vaccine A/H5N1 administered with and without a heat-labile enterotoxin (LT) patch in healthy adults
    Glenn, G. M.
    Frech, S. A.
    Wen, J.
    Thomas, D. N.
    VACCINE, 2008,
  • [49] A potential protein-based vaccine for influenza H5N1 from the recombinant HA1 domain of avian influenza A/H5N1 expressed in Pichia pastoris
    Thi Quy Nguyen
    Thi Thu Hao Van
    Lin, Yu-Chen
    Thi Nhu Ngoc Van
    Khanh Chi Bui
    Quynh Giang Le
    Thi Huyen Do
    Thi Thu Hong Le
    Viet Cuong Vo
    Van Dung Truong
    Smooker, Peter M.
    Coloe, Peter J.
    Nam Hai Truong
    FUTURE VIROLOGY, 2014, 9 (12) : 1019 - 1031
  • [50] Are we ready for pandemic influenza H5N1?
    Stephenson, I
    EXPERT REVIEW OF VACCINES, 2005, 4 (02) : 151 - 155
12345