Systemic Therapy of Cholangiocarcinoma

被引：21

作者：

Plentz, Ruben R. ^{[1
]}

Malek, Nisar P. ^{[1
]}

机构：

[1] Med Univ Hosp, Dept Internal Med 1, Otfried Muller Str 10, D-72076 Tubingen, Germany

来源：

VISCERAL MEDICINE | 2016年 / 32卷 / 06期

关键词：

Chemotherapy; Cholangiocarcinoma; Survival; BILIARY-TRACT CANCER; PHASE-II TRIAL; INTRAHEPATIC CHOLANGIOCARCINOMA; GALLBLADDER CARCINOMA; 1ST-LINE TREATMENT; HER2; EXPRESSION; PLUS SORAFENIB; OPEN-LABEL; GEMCITABINE; OXALIPLATIN;

D O I：

10.1159/000453084

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Cholangiocarcinoma (CC) is the second most common primary malignant liver disease. During the last decades, various novel therapies have been introduced in the field of oncology; nevertheless, the number of treatment options for CC is still limited. Methods: In this article, current palliative chemotherapy concepts as well as new drug therapies are outlined. Results: Gemcitabine and cisplatin are the standard treatment of care for patients with inoperable CC. Second-line chemotherapy is not standardized yet and is dependent on the first-line compounds. Antibodies against VEGFR and EGFR showed mixed or negative results. New molecular systemic treatments are not established yet. Conclusion: Many clinical trials are still ongoing and new therapeutic strategies, including immunotherapies, are under active investigation. (C) 2016 S. Karger GmbH, Freiburg

引用

页码：427 / 430

页数：4

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