Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka

被引：5

作者：

Grifoni, Alba ^{[1
]}

Weiskopf, Daniela ^{[1
]}

Arlehamn, Cecilia S. Lindestam ^{[1
]}

Angelo, Michael ^{[1
]}

Leary, Shay ^{[2
]}

Sidney, John ^{[1
]}

Frazier, April ^{[1
]}

Phillips, Elizabeth ^{[2
,3
]}

Mallal, Simon ^{[2
,3
]}

Mack, Steven J. ^{[4
]}

Tippalagama, Rashmi ^{[5
]}

Goonewardana, Suraj ^{[5
]}

Premawansa, Sunil ^{[6
]}

Premawansa, Gayani ^{[7
]}

Wijewickrama, Ananda ^{[8
]}

De Silva, Aruna D. ^{[1
,5
]}

Sette, Alessandro ^{[1
,9
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA

[2] Murdoch Univ, Inst Immunol & Infect Dis, Perth, WA 6150, Australia

[3] Vanderbilt Univ, Sch Med, Nashville, TN 37235 USA

[4] Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA

[5] Genetech Res Inst, Colombo, Sri Lanka

[6] Univ Colombo, Sci Fac, Dept Zool & Environm Sci, Colombo, Sri Lanka

[7] North Colombo Teaching Hosp, Ragama, Colombo, Sri Lanka

[8] Natl Inst Infect Dis, Gothatuwa, Angoda, Sri Lanka

[9] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

HUMAN IMMUNOLOGY | 2018年 / 79卷 / 02期

基金：

美国国家卫生研究院;

关键词：

HLA alleles; HLA typing; Colombo; Sri Lanka; Sinhalese; Tamil; Moors;

D O I：

10.1016/j.humimm.2017.12.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proportions were not detected at any locus. Several alleles were found in > 30% of individuals, including the class II alleles DPB1 * 04:01, DPB1 * 02:01, DQB1 * 06:01 and DRB1 * 07:01, and the class I alleles A * 33:03 and A * 24:02. Genotype data will be available in the Allele Frequencies Net Database.

引用

页码：87 / 88

页数：2

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