Subaortic stenosis in the Newfoundland: heredity, pathophysiology, diagnosis, prognosis and breeding advice

被引：0

作者：

Caestecker, K. ^{[1
]}

Peelman, L. ^{[2
]}

Bavegems, V. ^{[3
]}

机构：

[1] Univ Ghent, Fac Diergeneeskunde, Vakgroep Vergelijkende Fysiol & Biometrie, Salisburylaan 133, B-9820 Merelbeke, Belgium

[2] Univ Ghent, Fac Diergeneeskunde, Vakgroep Voeding Genet & Ethol, B-9820 Merelbeke, Belgium

[3] Univ Ghent, Fac Diergeneeskunde, Vakgroep Geneeskunde & Klin Biol Kleine Huisdiere, B-9820 Merelbeke, Belgium

来源：

VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT | 2012年 / 81卷 / 03期

关键词：

AORTIC-STENOSIS; DOGS;

D O I：

10.21825/vdt.v81i3.18350

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Subaortic stenosis is a narrowing of the left ventricular outflow tract just below the aortic valve, and is one of the most diagnosed congenital inherited heart diseases in the Newfoundland. The classification of subaortic stenosis is based on the lesions or the findings on echocardiography. Although the mode of inheritance is uncertain, a dominant trait with variable penetrance is generally accepted. The Epidermal Growth Factor Receptor oncogene is, together with the Ptim11-gene, a possible candidate gene to be involved in this disease. The diagnosis is particulary based on auscultation and echocardiography. The prognosis is variable and breeding advice is based on echocardiographic screening at the age of eighteen months; however, it remains a difficult issue.

引用

页码：138 / 148

页数：11

共 16 条

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