Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease

被引：585

作者：

Jenq, Robert R. ^{[1
,2
]}

Taur, Ying ^{[2
,3
]}

Devlin, Sean M. ^{[4
]}

Ponce, Doris M. ^{[1
,2
]}

Goldberg, Jenna D. ^{[1
,2
]}

Ahr, Katya F. ^{[5
]}

Littmann, Eric R. ^{[3
]}

Ling, Lilan ^{[5
]}

Gobourne, Asia C. ^{[5
]}

Miller, Liza C. ^{[5
]}

Docampo, Melissa D. ^{[5
]}

Peled, Jonathan U. ^{[1
,2
]}

Arpaia, Nicholas ^{[5
]}

Cross, Justin R. ^{[6
]}

Peets, Tatanisha K. ^{[7
]}

Lumish, Melissa A. ^{[5
]}

Shono, Yusuke ^{[5
]}

Dudakov, Jarrod A. ^{[5
]}

Poeck, Hendrik ^{[5
]}

Hanash, Alan M. ^{[1
,2
]}

Barker, Juliet N. ^{[1
,2
]}

Perales, Miguel-Angel ^{[1
,2
]}

Giralt, Sergio A. ^{[1
,2
]}

Pamer, Eric G. ^{[2
,3
]}

van den Brink, Marcel R. M. ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Adult BMT, New York, NY 10065 USA

[2] Weill Cornell Med Coll, New York, NY USA

[3] Mem Sloan Kettering Canc Ctr, Dept Med, Infect Dis Serv, New York, NY 10065 USA

[4] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA

[5] Mem Sloan Kettering Canc Ctr, Dept Immunol, New York, NY 10065 USA

[6] Mem Sloan Kettering Canc Ctr, Cell Metab Core, New York, NY 10065 USA

[7] Mem Sloan Kettering Canc Ctr, Dept Nutr, New York, NY 10065 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2015年 / 21卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Intestinal bacteria; Graft-versus-host disease; STEM-CELL TRANSPLANTATION; MARROW-TRANSPLANTATION; RISK-FACTORS; PROTECTIVE ISOLATION; SECONDARY DISEASE; STOOL MICROBIOME; EARLY OUTCOMES; ACUTE GVHD; SP NOV; SURVIVAL;

D O I：

10.1016/j.bbmt.2015.04.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The relationship between intestinal microbiota composition and acute graft-versus-host disease (GVHD) after allogeneic blood/marrow transplantation (allo-BMT) is not well understood. Intestinal bacteria have long been thought to contribute to GVHD pathophysiology, but recent animal studies in nontransplant settings have found that anti-inflammatory effects are mediated by certain subpopulations of intestinal commensals. Hypothesizing that a more nuanced relationship may exist between the intestinal bacteria and GVHD, we evaluated the fecal bacterial composition of 64 patients 12 days after BMT. We found that increased bacterial diversity was associated with reduced GVHD-related mortality. Furthermore, harboring increased amounts of bacteria belonging to the genus Blautia was associated with reduced GVHD lethality in this cohort and was confirmed in another independent cohort of 51 patients from the same institution. Blautia abundance was also associated with improved overall survival. We evaluated the abundance of Blautia with respect to clinical factors and found that loss of Blautia was associated with treatment with antibiotics that inhibit anaerobic bacteria and receiving total parenteral nutrition for longer durations. We conclude that increased abundance of commensal bacteria belonging to the Blautia genus is associated with reduced lethal GVHD and improved overall survival. (C) 2015 American Society for Blood and Marrow Transplantation.

引用

页码：1373 / 1383

页数：11

共 56 条

[1] Biomarkers of Myocardial Stress and Fibrosis as Predictors of Mode of Death in Patients With Chronic Heart Failure [J].

Ahmad, Tariq ;

Fiuzat, Mona ;

Neely, Benjamin ;

Neely, Megan L. ;

Pencina, Michael J. ;

Kraus, William E. ;

Zannad, Faiez ;

Whellan, David J. ;

Donahue, Mark P. ;

Pina, Ileana L. ;

Adams, Kirkwood F. ;

Kitzman, Dalane W. ;

O'Connor, Christopher M. ;

Felker, G. Michael .

JACC-HEART FAILURE, 2014, 2 (03) :260-268

[2]

[Anonymous], 2013, CURRENT USE OUTCOME

[3] Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Oshima, Kenshiro ;

Suda, Wataru ;

Nagano, Yuji ;

Nishikawa, Hiroyoshi ;

Fukuda, Shinji ;

Saito, Takuro ;

Narushima, Seiko ;

Hase, Koji ;

Kim, Sangwan ;

Fritz, Joelle V. ;

Wilmes, Paul ;

Ueha, Satoshi ;

Matsushima, Kouji ;

Ohno, Hiroshi ;

Olle, Bernat ;

Sakaguchi, Shimon ;

Taniguchi, Tadatsugu ;

Morita, Hidetoshi ;

Hattori, Masahira ;

Honda, Kenya .

NATURE, 2013, 500 (7461) :232-+

[4] Defining the Intensity of Conditioning Regimens: Working Definitions [J].

Bacigalupo, Andrea ;

Ballen, Karen ;

Rizzo, Doug ;

Giralt, Sergio ;

Lazarus, Hillard ;

Ho, Vincent ;

Apperley, Jane ;

Slavin, Shimon ;

Pasquini, Marcelo ;

Sandmaier, Brenda M. ;

Barrett, John ;

Blaise, Didier ;

Lowski, Robert ;

Horowitz, Mary .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2009, 15 (12) :1628-1633

[5] Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation [J].

Bajaj, Jasmohan S. ;

Hylemon, Phillip B. ;

Ridlon, Jason M. ;

Heuman, Douglas M. ;

Daita, Kalyani ;

White, Melanie B. ;

Monteith, Pamela ;

Noble, Nicole A. ;

Sikaroodi, Masoumeh ;

Gillevet, Patrick M. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 303 (06) :G675-G685

[6]

Barrell Catherine, 2012, Oncol Nurs Forum, V39, pE451, DOI 10.1188/12.ONF.E451-E458

[7] Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies:: Final results and long-term follow-up of an open-label prospective randomized trial [J].

Beelen, DW ;

Elmaagacli, A ;

Müller, KD ;

Hirche, H ;

Schaefer, UW .

BLOOD, 1999, 93 (10) :3267-3275

[8] QIIME allows analysis of high-throughput community sequencing data [J].

Caporaso, J. Gregory ;

Kuczynski, Justin ;

Stombaugh, Jesse ;

Bittinger, Kyle ;

Bushman, Frederic D. ;

Costello, Elizabeth K. ;

Fierer, Noah ;

Pena, Antonio Gonzalez ;

Goodrich, Julia K. ;

Gordon, Jeffrey I. ;

Huttley, Gavin A. ;

Kelley, Scott T. ;

Knights, Dan ;

Koenig, Jeremy E. ;

Ley, Ruth E. ;

Lozupone, Catherine A. ;

McDonald, Daniel ;

Muegge, Brian D. ;

Pirrung, Meg ;

Reeder, Jens ;

Sevinsky, Joel R. ;

Tumbaugh, Peter J. ;

Walters, William A. ;

Widmann, Jeremy ;

Yatsunenko, Tanya ;

Zaneveld, Jesse ;

Knight, Rob .

NATURE METHODS, 2010, 7 (05) :335-336

[9] Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer [J].

Chen, Weiguang ;

Liu, Fanlong ;

Ling, Zongxin ;

Tong, Xiaojuan ;

Xiang, Charlie .

PLOS ONE, 2012, 7 (06)

[10] Detection of Bacterial 16S rRNA and Identification of Four Clinically Important Bacteria by Real-Time PCR [J].

Clifford, Robert J. ;

Milillo, Michael ;

Prestwood, Jackson ;

Quintero, Reyes ;

Zurawski, Daniel V. ;

Kwak, Yoon I. ;

Waterman, Paige E. ;

Lesho, Emil P. ;

Mc Gann, Patrick .

PLOS ONE, 2012, 7 (11)

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