Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis

被引：524
作者：
Gomaa, Asmaa Ibrahim [1 ,2 ]
Khan, Shahid A. [1 ]
Toledano, Mireille B. [3 ]
Waked, Imam [2 ]
Taylor-Robinson, Simon D. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Gastroenterol & Hepatol, London W2 1NY, England
[2] Menoufia Univ, Natl Liver Unit, Shibin Al Kawm 32111, Egypt
[3] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London W2 1PG, England
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 27期
基金：
英国医学研究理事会;
关键词：
hepatocellular carcinoma; epidemiology; risk factors; aetiology; pathogenesis;
D O I：
10.3748/wjg.14.4300
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Given that the burden of chronic liver disease is expected to rise owing to increasing rates of alcoholism, hepatitis B and C prevalence and obesity-related fatty liver disease, it is expected that the incidence of HCC will also increase in the foreseeable future. This article summarizes the international epidemiology, the risk factors and the pathogenesis of HCC, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance. (c) 2008 The WJG Press. All rights reserved.
引用
收藏
页码：4300 / 4308
页数：9
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